Type

Journal Article

Authors

R Paul Ross
Aidan Coffey
Colin Hill
Catherine Stanton
Fergus Shanahan
Susan Mills

Subjects

Microbiology

Topics
intestinal microbiota this review intestinal diseases human microbiota immune system human health gut microbiota life cycle

Movers and shakers: Influence of bacteriophages in shaping the mammalian gut microbiota. (2012)

Abstract The human intestinal microbiota is one of the most densely populated ecosystems on Earth, containing up to 10 ( 13) bacteria/g and in some respects can be considered an organ itself given its role in human health. Bacteriophages (phages) are the most abundant replicating entities on the planet and thrive wherever their bacterial hosts exist. They undoubtedly influence the dominant microbial populations in many ecosystems including the human intestine. Within this setting, lysogeny appears to be the preferred life cycle, presumably due to nutrient limitations and lack of suitable hosts protected in biofilms, hence the predator/prey dynamic observed in many ecosystems is absent. On the other hand, free virulent phages in the gut are more common among sufferers of intestinal diseases and have been shown to increase with antibiotic usage. Many of these phages evolve from prophages of intestinal bacteria and emerge under conditions where their bacterial hosts encounter stress suggesting that prophages can significantly alter the microbial community composition. Based on these observations, we propose the "community shuffling" model which hypothesizes that prophage induction contributes to intestinal dysbiosis by altering the ratio of symbionts to pathobionts, enabling pathobiont niche reoccupation. The consequences of the increased phage load on the mammalian immune system are also addressed. While this is an area of intestinal biology which has received little attention, this review assembles evidence from the literature which supports the role of phages as one of the biological drivers behind the composition of the gut microbiota.
Collections Ireland -> Teagasc -> PubMed

Full list of authors on original publication

R Paul Ross, Aidan Coffey, Colin Hill, Catherine Stanton, Fergus Shanahan, Susan Mills

Experts in our system

1
R Paul Ross
Teagasc
Total Publications: 441
 
2
Aidan Coffey
Teagasc
Total Publications: 63
 
3
Colin Hill
University College Cork
Total Publications: 351
 
4
Catherine Stanton
Teagasc
Total Publications: 261
 
5
Fergus Shanahan
University College Cork
Total Publications: 237
 
6
Susan Mills
Teagasc
Total Publications: 15