Type

Journal Article

Authors

Colin Hill
R Paul Ross
Barry Kiely
Eamonn M M Quigley
Fergus Shanahan
Mary C. Rea
Evelyn M Clayton

Subjects

Microbiology

Topics
clostridium infections young adult aged polymerase chain reaction epidemiology middle aged adult electrophoresis gel pulsed field humans ribotyping carrier state prevalence clostridium difficile female genetics microbiology ambulatory care classification isolation purification irritable bowel syndrome

Carriage of Clostridium difficile in outpatients with irritable bowel syndrome. (2012)

Abstract Irritable bowel syndrome (IBS) is a common, typically chronic and sometimes disabling gastrointestinal condition of uncertain aetiology. Recently, a variety of links to gastrointestinal infections have been described including the onset of IBS following exposure to enteric pathogens and an apparent predisposition to gastrointestinal infection. The prevalence of Clostridium difficile in a population of IBS outpatients (n = 87) in the absence of established risk factors for the acquisition of C. difficile infection was examined. Overall, 5.7 % of patients (n = 5) carried culturable C. difficile and 4.6 % (n = 4) of isolates were toxigenic, belonging to toxinotype group 0, compared with 1.1 % (n = 1) for the healthy control group (n = 88). These isolates were members of toxigenic PCR ribotype groups 005 and 050 (IBS group) and 062 (control group) and were identified further as three individual strains by PFGE. Although no significant difference was observed between IBS patients and healthy volunteers, these findings support the concept that a subpopulation of IBS patients may be susceptible to gastrointestinal infection.
Collections Ireland -> Teagasc -> PubMed

Full list of authors on original publication

Colin Hill, R Paul Ross, Barry Kiely, Eamonn M M Quigley, Fergus Shanahan, Mary C. Rea, Evelyn M Clayton

Experts in our system

1
Colin Hill
University College Cork
Total Publications: 351
 
2
R Paul Ross
Teagasc
Total Publications: 441
 
3
Barry Kiely
University College Cork
Total Publications: 21
 
4
Eamonn M M Quigley
University College Cork
Total Publications: 114
 
5
Fergus Shanahan
University College Cork
Total Publications: 237
 
6
Mary C. Rea
Teagasc
Total Publications: 68
 
7
Evelyn M Clayton
Teagasc
Total Publications: 7