Type

Journal Article

Authors

Colin Hill
R Paul Ross
Michael Cronin
P Brendan Lynch
Peadar G Lawlor
Sheila M Morgan
Paula O'Connor
Brid O'Riordan
Mary C. Rea
Gillian E. Gardiner

Subjects

Pharmacology

Topics
lacticin 3147 bacteriocins gastrointestinal tract alpha chymotrypsin lacticin 481 metabolism adverse effects chymotrypsin

Fate of the two-component lantibiotic lacticin 3147 in the gastrointestinal tract. (2007)

Abstract The component peptides of lacticin 3147 were degraded by alpha-chymotrypsin in vitro with a resultant loss of antimicrobial activity. Activity was also lost in ileum digesta. Following oral ingestion, neither of the lacticin 3147 peptides was detected in the gastric, jejunum, or ileum digesta of pigs, and no lacticin 3147 activity was found in the feces. These observations suggest that lacticin 3147 ingestion is unlikely to have adverse effects, since it is probably inactivated during intestinal transit.
Collections Ireland -> Teagasc -> PubMed

Full list of authors on original publication

Colin Hill, R Paul Ross, Michael Cronin, P Brendan Lynch, Peadar G Lawlor, Sheila M Morgan, Paula O'Connor, Brid O'Riordan, Mary C. Rea, Gillian E. Gardiner

Experts in our system

1
Colin Hill
University College Cork
Total Publications: 351
 
2
R Paul Ross
Teagasc
Total Publications: 441
 
4
Paula M. O'Connor
Teagasc
Total Publications: 85
 
5
Mary C. Rea
Teagasc
Total Publications: 68
 
6
Gillian E. Gardiner
Teagasc
Total Publications: 55