Type

Journal Article

Authors

William Meaney
Paul Ross
Colin Hill
James Flynn
Denis Twomey
Fiona Crispie

Subjects

Veterinary

Topics
colony count microbial staphylococcal infections staphylococcus aureus pharmacology lactation culture media drug effects bacteriocins mastitis bovine female prevention control cattle mammary glands animal lacticin 481 animals microbiology biosynthesis bismuth anti bacterial agents veterinary

The lantibiotic lacticin 3147 produced in a milk-based medium improves the efficacy of a bismuth-based teat seal in cattle deliberately infected with Staphylococcus aureus. (2005)

Abstract A preparation of the bacteriocin lacticin 3147 (prepared from a demineralized whey protein fermentation liquor) was combined as a powder with a bismuth-based intramammary teat seal and evaluated for its potential as an antimicrobial in non-lactating cows. The lacticin/teat seal formulation enabled significant bacteriocin release from the seal without the requirement for a surfactant. Studies in vivo in lactating cows demonstrated that this formulation was effective in reducing bacterial recoveries (approximately 20-fold) from teats deliberately inoculated with Staphylococcus aureus after infusion. Moreover, this formulation also significantly reduced the numbers of Staph. aureus recovered from teats that were exposed to the challenge bacterium before the infusion of the teat seal preparation. The powdered preparation of lacticin 3147 did, however, cause some teat irritation as evidenced by associated rises in somatic cell count (SCC). However, this effect was short-lived and when the mean SCC readings pre-infusion and the final two readings post-infusion were compared, there was no significant difference in the immunological acceptance between treatments.
Collections Ireland -> Teagasc -> PubMed

Full list of authors on original publication

William Meaney, Paul Ross, Colin Hill, James Flynn, Denis Twomey, Fiona Crispie

Experts in our system

1
Paul Ross
University College Cork
Total Publications: 29
 
2
Colin Hill
University College Cork
Total Publications: 351
 
3
James Flynn
Teagasc
Total Publications: 15
 
4
Fiona Crispie
Teagasc
Total Publications: 30