Type

Journal Article

Authors

C Hill
Billy Meaney
Maire Ryan
R P Ross
Denis Twomey

Subjects

Biochemistry

Topics
physiology lactobacillus peptides protein structure secondary therapeutic use genetics chemistry amino acid sequence molecular sequence data sequence homology amino acid sequence alignment biosynthesis anti bacterial agents

Lantibiotics produced by lactic acid bacteria: structure, function and applications. (2002)

Abstract Lantibiotics are a diverse group of heavily modified antimicrobial and/or signalling peptides produced by a wide range of bacteria, including a variety of lactic acid bacteria. Based on their diverse structures and mode of action, at least six separate lantibiotic subgroups can be suggested, but all subgroups are characterized by significant post-translational modifications, which include the formation of (beta-methyl)lanthionines, among other unusual alterations. These small peptides are produced, modified, exported, sensed and combated by a complex set of proteins encoded by (usually) co-ordinately regulated operons. In some instances, the production and immunity have been shown to be auto-regulated by the mature lantibiotic. Since their discovery, interest in lantibiotics has been fuelled by their obvious potential as food-grade antimicrobials to improve food safety and quality; a potential which, to date, has been realised only by the longest characterised molecule, nisin. In addition, these peptides are often mooted as alternatives to antibiotics for some biomedical applications. The purpose of this paper is to review recent developments in our understanding of lantibiotic structure, molecular genetics and applications for this unusual class of bacteriocins.
Collections Ireland -> Teagasc -> PubMed

Full list of authors on original publication

C Hill, Billy Meaney, Maire Ryan, R P Ross, Denis Twomey

Experts in our system

1
Colin Hill
University College Cork
Total Publications: 351
 
2
R Paul Ross
Teagasc
Total Publications: 441