Journal Article


Daniel G Bradley
H Martin Vordermeier
R Glyn Hewinson
Douglas B Young
Abraham Aseffa
Elena Hailu
Gobena Ameni
Valeria Mattiangeli
Yonas Kassahun



candidate gene animals domestic holstein friesian toll like receptor genetic mapping population european tuberculosis in cattle

Admixture mapping of tuberculosis and pigmentation-related traits in an African-European hybrid cattle population. (2015)

Abstract Admixture mapping affords a powerful approach to genetic mapping of complex traits and may be particularly suited to investigation in cattle where many breeds and populations are hybrids of the two divergent ancestral genomes, derived from Bos taurus and Bos indicus. Here we design a minimal genome wide SNP panel for tracking ancestry in recent hybrids of Holstein-Friesian and local Arsi zebu in a field sample from a region of high bovine tuberculosis (BTB) endemicity in the central Ethiopian highlands. We first demonstrate the utility of this approach by mapping the red coat color phenotype, uncovering a highly significant peak over the MC1R gene and a second peak with no previously known candidate gene. Secondly, we exploit the described differential susceptibility to BTB between the ancestral strains to identify a region in which Bos taurus ancestry associates, at suggestive significance, with skin test positivity. Interestingly, this association peak contains the toll-like receptor gene cluster on chromosome 6. With this work we have shown the potential of admixture mapping in hybrid domestic animals with divergent ancestral genomes, a recurring condition in domesticated species.
Collections Ireland -> Trinity College Dublin -> PubMed

Full list of authors on original publication

Daniel G Bradley, H Martin Vordermeier, R Glyn Hewinson, Douglas B Young, Abraham Aseffa, Elena Hailu, Gobena Ameni, Valeria Mattiangeli, Yonas Kassahun

Experts in our system

Daniel Bradley
Trinity College Dublin
Total Publications: 84
Valeria Mattiangeli
Trinity College Dublin
Total Publications: 5