Type

Journal Article

Authors

Jessica A Turner
Vince D Calhoun
Gary Donohoe
Colm McDonald
Dara M. Cannon
Aiden Corvin
Derek Morris
Juan R Bustillo
Lei Wang
Stefan Ehrlich
and 6 others

Subjects

Psychiatry

Topics
variant corpus callosum single genotype influence genome wide association studies microrna 137 mir137 schizophrenia subcortical volume literature schizophrenia

MIR137HG risk variant rs1625579 genotype is related to corpus callosum volume in schizophrenia. (2015)

Abstract Genome-wide association studies implicate the MIR137HG risk variant rs1625579 (MIR137HGrv) within the host gene for microRNA-137 as a potential regulator of schizophrenia susceptibility. We examined the influence of MIR137HGrv genotype on 17 subcortical and callosal volumes in a large sample of individuals with schizophrenia and healthy controls (n=841). Although the volumes were overall reduced relative to healthy controls, for individuals with schizophrenia the homozygous MIR137HGrv risk genotype was associated with attenuated reduction of mid-posterior corpus callosum volume (p=0.001), along with trend-level effects in the adjacent central and posterior corpus callosum. These findings are unique in the literature and remain robust after analysis in ethnically homogenous and single-scanner subsets of the larger sample. Thus, our study suggests that the mechanisms whereby MIR137HGrv works to increase schizophrenia risk are not those that generate the corpus callosum volume reductions commonly found in the disorder.
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Full list of authors on original publication

Jessica A Turner, Vince D Calhoun, Gary Donohoe, Colm McDonald, Dara M. Cannon, Aiden Corvin, Derek Morris, Juan R Bustillo, Lei Wang, Stefan Ehrlich and 6 others

Experts in our system

1
Gary Donohoe
Trinity College Dublin
Total Publications: 130
 
2
Colm McDonald
National University of Ireland Galway
Total Publications: 43
 
3
Dara M. Cannon
National University of Ireland Galway
Total Publications: 29
 
4
Aiden Corvin
Trinity College Dublin
Total Publications: 190
 
5
Derek Morris
Trinity College Dublin
Total Publications: 150