Type

Journal Article

Authors

Richard B Reilly
Michael Hutchinson
Sean O'Riordan
Brendan Quinlivan
Okka Kimmich
Laura Williams
Anna Molloy
John S Butler

Subjects

Mathematics

Topics
threshold non parametric analysis standard deviation confidence intervals bootstrapping movement disorders control groups temporal discrimination

Non-parametric bootstrapping method for measuring the temporal discrimination threshold for movement disorders. (2015)

Abstract Recent studies have proposed that the temporal discrimination threshold (TDT), the shortest detectable time period between two stimuli, is a possible endophenotype for adult onset idiopathic isolated focal dystonia (AOIFD). Patients with AOIFD, the third most common movement disorder, and their first-degree relatives have been shown to have abnormal visual and tactile TDTs. For this reason it is important to fully characterize each participant's data. To date the TDT has only been reported as a single value. Here, we fit individual participant data with a cumulative Gaussian to extract the mean and standard deviation of the distribution. The mean represents the point of subjective equality (PSE), the inter-stimulus interval at which participants are equally likely to respond that two stimuli are one stimulus (synchronous) or two different stimuli (asynchronous). The standard deviation represents the just noticeable difference (JND) which is how sensitive participants are to changes in temporal asynchrony around the PSE. We extended this method by submitting the data to a non-parametric bootstrapped analysis to get 95% confidence intervals on individual participant data. Both the JND and PSE correlate with the TDT value but are independent of each other. Hence this suggests that they represent different facets of the TDT. Furthermore, we divided groups by age and compared the TDT, PSE, and JND values. The analysis revealed a statistical difference for the PSE which was only trending for the TDT. The analysis method will enable deeper analysis of the TDT to leverage subtle differences within and between control and patient groups, not apparent in the standard TDT measure.
Collections Ireland -> Trinity College Dublin -> PubMed

Full list of authors on original publication

Richard B Reilly, Michael Hutchinson, Sean O'Riordan, Brendan Quinlivan, Okka Kimmich, Laura Williams, Anna Molloy, John S Butler

Experts in our system

1
Richard Reilly
Trinity College Dublin
Total Publications: 185
 
2
Michael Hutchinson
University College Dublin
Total Publications: 79
 
3
Sean O'Riordan
Trinity College Dublin
Total Publications: 20
 
4
Brendan Quinlivan
University College Dublin
Total Publications: 11
 
5
Okka Kimmich
Trinity College Dublin
Total Publications: 8
 
6
Laura Williams
Trinity College Dublin
Total Publications: 15
 
7
Anna Molloy
Trinity College Dublin
Total Publications: 8
 
8
John S Butler
Dublin Institute of Technology
Total Publications: 28