Type

Journal Article

Authors

Michael D Greicius
Jean-Baptiste Poline
Mike Hawrylycz
Gunter Schumann
Andreas Ströhle
Rainer Spanagel
Michael N Smolka
Trevor W Robbins
Marcella Rietschel
Zdenka Pausova
and 23 others

Subjects

Biochemistry

Topics
brain male young adult mice synapses adult magnetic resonance imaging humans physiology gene expression rest polymorphism genetic adolescent animals ion channels female genetics transcriptome metabolism nerve net neural pathways

BRAIN NETWORKS. Correlated gene expression supports synchronous activity in brain networks. (2014)

Abstract During rest, brain activity is synchronized between different regions widely distributed throughout the brain, forming functional networks. However, the molecular mechanisms supporting functional connectivity remain undefined. We show that functional brain networks defined with resting-state functional magnetic resonance imaging can be recapitulated by using measures of correlated gene expression in a post mortem brain tissue data set. The set of 136 genes we identify is significantly enriched for ion channels. Polymorphisms in this set of genes significantly affect resting-state functional connectivity in a large sample of healthy adolescents. Expression levels of these genes are also significantly associated with axonal connectivity in the mouse. The results provide convergent, multimodal evidence that resting-state functional networks correlate with the orchestrated activity of dozens of genes linked to ion channel activity and synaptic function.
Collections Ireland -> Trinity College Dublin -> PubMed

Full list of authors on original publication

Michael D Greicius, Jean-Baptiste Poline, Mike Hawrylycz, Gunter Schumann, Andreas Ströhle, Rainer Spanagel, Michael N Smolka, Trevor W Robbins, Marcella Rietschel, Zdenka Pausova and 23 others

Experts in our system

1
Gunter Schumann
Trinity College Dublin
Total Publications: 65
 
2
Michael N Smolka
Trinity College Dublin
Total Publications: 65
 
3
Trevor W Robbins
Trinity College Dublin
Total Publications: 25
 
4
Marcella Rietschel
Trinity College Dublin
Total Publications: 40