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Elizabeth Forde
Michelle Leech
Kathryn Mulryan


Medicine & Nursing

cell survival cancer survival clinical trials radiation therapy this review small cell lung cancer non small cell lung rib fractures

Effect of stereotactic dosimetric end points on overall survival for Stage I non-small cell lung cancer: A critical review. (2014)

Abstract Stereotactic body radiation therapy (SBRT) delivers a high biologically effective dose while minimizing toxicities to surrounding tissues. Within the scope of clinical trials and local practice, there are inconsistencies in dosimetrics used to evaluate plan quality. The purpose of this critical review was to determine if dosimetric parameters used in SBRT plans have an effect on local control (LC), overall survival (OS), and toxicities. A database of relevant trials investigating SBRT for patients with early-stage non-small cell lung cancer was compiled, and a table of dosimetric variables used was created. These parameters were compared and contrasted for LC, OS, and toxicities. Dosimetric end points appear to have no effect on OS or LC. Incidences of rib fractures correlate with a lack of dose-volume constraints (DVCs) reported. This review highlights the great disparity present in clinical trials reporting dosimetrics, DVCs, and toxicities for lung SBRT. Further evidence is required before standard DVCs guidelines can be introduced. Dosimetric end points specific to stereotactic treatment planning have been proposed but require further investigation before clinical implementation.
Collections Ireland -> Trinity College Dublin -> PubMed

Full list of authors on original publication

Elizabeth Forde, Michelle Leech, Kathryn Mulryan

Experts in our system

Elizabeth Forde
Trinity College Dublin
Total Publications: 4
Michelle Leech
Trinity College Dublin
Total Publications: 18