Journal Article


Marina A Lynch
Kingston H G Mills
Róisín M McManus



this review feature immune system pathology brain patients t cells neurofibrillary tangles

T Cells-Protective or Pathogenic in Alzheimer's Disease? (2015)

Abstract Alzheimer's disease (AD) is the most common cause of dementia, and is characterised by deposits of amyloid β (Aβ), neurofibrillary tangles and neuronal loss. Neuroinflammatory changes have been identified as a feature of the disease, and recent studies have suggested a potential role for the peripheral immune system in driving these changes and, ultimately, the associated neuronal degeneration. A number of reports have detailed changes in the activation state and subtype of T cells in the circulation and CSF of AD patients and there is evidence of T cell infiltration into the brain. In this review, we examine the possible impact of T cell infiltration in the progression of pathology in AD and consider the data obtained from animal models of the disease. We consider how these cells infiltrate the brain, particularly in AD, and discuss whether the presence of T cells in the AD brain is protective or pathogenic. Finally we evaluate the current therapies, particularly those that involve immunization.
Collections Ireland -> Trinity College Dublin -> PubMed

Full list of authors on original publication

Marina A Lynch, Kingston H G Mills, Róisín M McManus

Experts in our system

Marina Annetta Lynch
Trinity College Dublin
Total Publications: 80
Kingston Mills
Trinity College Dublin
Total Publications: 182
Róisín M McManus
Trinity College Dublin
Total Publications: 5