Type

Journal Article

Authors

E M Creagh
E Kay
G A Doherty
E J Ryan
K Sheahan
K H G Mills
Z Heetun
F Caiazza
A O'Grady
J Fay
and 3 others

Subjects

Biochemistry

Topics
biosynthesis casp5 protein human colorectal neoplasms caspases initiator pathology cytology male biological markers colitis ulcerative adult casp4 protein human inflammation young adult caspases aged humans middle aged female intestinal mucosa epithelial cells diagnosis metabolism

Altered expression of caspases-4 and -5 during inflammatory bowel disease and colorectal cancer: Diagnostic and therapeutic potential. (2015)

Abstract Caspases are a group of proteolytic enzymes involved in the co-ordination of cellular processes, including cellular homeostasis, inflammation and apoptosis. Altered activity of caspases, particularly caspase-1, has been implicated in the development of intestinal diseases, such as inflammatory bowel disease (IBD) and colorectal cancer (CRC). However, the involvement of two related inflammatory caspase members, caspases-4 and -5, during intestinal homeostasis and disease has not yet been established. This study demonstrates that caspases-4 and -5 are involved in IBD-associated intestinal inflammation. Furthermore, we found a clear correlation between stromal caspase-4 and -5 expression levels, inflammation and disease activity in ulcerative colitis patients. Deregulated intestinal inflammation in IBD patients is associated with an increased risk of developing CRC. We found robust expression of caspases-4 and -5 within intestinal epithelial cells, exclusively within neoplastic tissue, of colorectal tumours. An examination of adjacent normal, inflamed and tumour tissue from patients with colitis-associated CRC confirmed that stromal expression of caspases-4 and -5 is increased in inflamed and dysplastic tissue, while epithelial expression is restricted to neoplastic tissue. In addition to identifying caspases-4 and -5 as potential targets for limiting intestinal inflammation, this study has identified epithelial-expressed caspases-4 and -5 as biomarkers with diagnostic and therapeutic potential in CRC.
Collections Ireland -> Trinity College Dublin -> PubMed

Full list of authors on original publication

E M Creagh, E Kay, G A Doherty, E J Ryan, K Sheahan, K H G Mills, Z Heetun, F Caiazza, A O'Grady, J Fay and 3 others

Experts in our system

1
Emma Creagh
Trinity College Dublin
Total Publications: 22
 
2
Elaine W Kay
Royal College of Surgeons in Ireland
Total Publications: 157
 
3
Glen A Doherty
University College Dublin
Total Publications: 57
 
4
Elizabeth J Ryan
University College Dublin
 
5
Kieran Sheahan
University College Dublin
Total Publications: 40
 
6
Kingston Mills
Trinity College Dublin
Total Publications: 182
 
7
Anthony O'Grady
Royal College of Surgeons in Ireland
Total Publications: 35
 
8
Joanna Fay
Royal College of Surgeons in Ireland
Total Publications: 24