Type

Journal Article

Authors

Yuri Volkov
Adriele Prina Mello
Marek W Radomski
Namrata Jain
Carlos Medina
Maria J Santos-Martinez
Stephen P Samuel
Carlos Medina Martin

Subjects

Chemistry

Topics
matrix metalloproteinase 2 p selectin cdte quantum dots nanoscience materials activation flow cytometry quartz crystal microbalance implications quantum dots nanoparticle human molecular imaging platelets microscopy phase contrast

CdTe quantum dots induce activation of human platelets: implications for nanoparticle hemocompatibility. (2015)

Abstract New nanomaterials intended for systemic administration have raised concerns regarding their biocompatibility and hemocompatibility. Quantum dots (QD) nanoparticles have been used for diagnostics, and recent work suggests their use for in vivo molecular and cellular imaging. However, the hemocompatibility of QDs and their constituent components has not been fully elucidated. In the present study, comprehensive investigation of QD-platelet interactions is presented. These interactions were shown using transmission electron microscopy. The effects of QDs on platelet function were investigated using light aggregometry, quartz crystal microbalance with dissipation, flow cytometry, and gelatin zymography. Platelet morphology was also analyzed by phase-contrast, immunofluorescence, atomic-force and transmission electron microscopy. We show that the QDs bind to platelet plasma membrane with the resultant upregulation of glycoprotein IIb/IIIa and P-selectin receptors, and release of matrix metalloproteinase-2. These findings unravel for the first time the mechanism of functional response of platelets to ultrasmall QDs in vitro.
Collections Ireland -> Trinity College Dublin -> Pharmacy and Pharmaceutical Sciences (Scholarly Publications)
Ireland -> Trinity College Dublin -> Pharmacy and Pharmaceutical Sciences
Ireland -> Trinity College Dublin -> RSS Feeds
Ireland -> Trinity College Dublin -> PubMed
Ireland -> Trinity College Dublin -> School of Pharmacy and Pharmaceutical Sciences
Ireland -> Trinity College Dublin -> RSS Feeds

Full list of authors on original publication

Yuri Volkov, Adriele Prina Mello, Marek W Radomski, Namrata Jain, Carlos Medina, Maria J Santos-Martinez, Stephen P Samuel, Carlos Medina Martin

Experts in our system

1
Yuri Volkov
Trinity College Dublin
Total Publications: 70
 
2
Adriele Prina Mello
Trinity College Dublin
Total Publications: 30
 
3
Marek W Radomski
Trinity College Dublin
Total Publications: 44
 
4
Namrata Jain
Trinity College Dublin
Total Publications: 5
 
5
Carlos Medina
Trinity College Dublin
Total Publications: 23
 
6
Maria Jose Santos-Martinez
Trinity College Dublin
Total Publications: 29
 
7
Carlos Medina Martin
Trinity College Dublin
Total Publications: 28