Type

Journal Article

Authors

Linda Booij
Michael Gill
James Meaney
Ciara Fahey
Derek Morris
Farida Vaisheva
Sergiy Dymov
Victoria Ly
Angela Carballedo
Moshe Szyf
and 1 others

Subjects

Psychiatry

Topics
brain function site specific major depressive disorder mdd serotonin cognitive control processing dna methylation gene

DNA methylation of the serotonin transporter gene (SLC6A4) is associated with brain function involved in processing emotional stimuli. (2015)

Abstract The aim of the present study was to investigate the association of fMRI blood oxygen-level dependent (BOLD) reactivity with the level of epigenetic methylation of SLC6A4 in blood DNA from a sample of healthy participants and patients with major depressive disorder (MDD). We investigated patients with MDD and healthy controls using fMRI and an emotional attention-shifting task. We assessed site-specific DNA methylation of a previously characterized SLC6A4 region in peripheral blood DNA using pyrosequencing. Our study involved 25 patients with MDD and 35 healthy controls. Activation in the anterior insula elicited by negative emotional content was significantly positively associated with the degree of SLC6A4 methylation. Significantly negative associations were observed between activation in the posterior insula and the degree of SLC6A4 methylation when judging the geometry of pictures after seeing negative in contrast to positive emotional stimuli. Healthy controls with a high degree of SLC6A4 methylation depicted significantly more activity elicited by positive stimuli in limbic regions and more activity elicited by negative stimuli in limbic as well as cognitive control regions than those with a low degree of SLC6A4 methylation. It is impossible to measure methylation directly in the brain and thus we assessed peripheral methylation of SLC6A4. Since the association was cross-sectional, no conclusion about cause and effect can be drawn. Our study provides further support to the hypothesis that particular DNA methylation states that are associated with brain function during emotion processing are detectable in the periphery.
Collections Ireland -> Trinity College Dublin -> PubMed

Full list of authors on original publication

Linda Booij, Michael Gill, James Meaney, Ciara Fahey, Derek Morris, Farida Vaisheva, Sergiy Dymov, Victoria Ly, Angela Carballedo, Moshe Szyf and 1 others

Experts in our system

1
Michael Gill
Trinity College Dublin
Total Publications: 260
 
2
James Meaney
Trinity College Dublin
Total Publications: 25
 
3
Ciara Fahey
Trinity College Dublin
Total Publications: 30
 
4
Derek Morris
Trinity College Dublin
Total Publications: 150
 
5
Angela Carballedo
Trinity College Dublin
Total Publications: 23
 
6
Moshe Szyf
University College Dublin
Total Publications: 8