Type

Journal Article

Authors

Anne Barton
Andre Reis
Harald Burkhardt
Frank Behrens
Pauline Ho
Matthew A Brown
Neil McHugh
Oliver FitzGerald
Ross Mcmanus
Jonathan Packham
and 22 others

Subjects

Medicine & Nursing

Topics
genetics genetic loci association study case control study genotyping t cells inflammatory arthritis psoriatic arthritis psa

Dense genotyping of immune-related susceptibility loci reveals new insights into the genetics of psoriatic arthritis. (2014)

Abstract Psoriatic arthritis (PsA) is a chronic inflammatory arthritis associated with psoriasis and, despite the larger estimated heritability for PsA, the majority of genetic susceptibility loci identified to date are shared with psoriasis. Here, we present results from a case-control association study on 1,962 PsA patients and 8,923 controls using the Immunochip genotyping array. We identify eight loci passing genome-wide significance, secondary independent effects at three loci and a distinct PsA-specific variant at the IL23R locus. We report two novel loci and evidence of a novel PsA-specific association at chromosome 5q31. Imputation of classical HLA alleles, amino acids and SNPs across the MHC region highlights three independent associations to class I genes. Finally, we find an enrichment of associated variants to markers of open chromatin in CD8(+) memory primary T cells. This study identifies key insights into the genetics of PsA that could begin to explain fundamental differences between psoriasis and PsA.
Collections Ireland -> Trinity College Dublin -> PubMed

Full list of authors on original publication

Anne Barton, Andre Reis, Harald Burkhardt, Frank Behrens, Pauline Ho, Matthew A Brown, Neil McHugh, Oliver FitzGerald, Ross Mcmanus, Jonathan Packham and 22 others

Experts in our system

1
Anne Barton
University College Dublin
Total Publications: 13
 
2
Neil McHugh
University College Dublin
 
3
Oliver FitzGerald
University College Dublin
Total Publications: 68
 
4
Ross Mcmanus
Trinity College Dublin