Type

Journal Article

Authors

Thomas Connor
Andrew Harkin
Martina Mary Hughes
Michael Gill
Derrek Morris
Norbert Skokauskas
Veronica O'Keane
Eva-Maria Frey
Angela Carballedo
Thomas Frodl

Subjects

Psychiatry

Topics
mental stress patients regression analysis high resolution genes expression magnetic resonance imaging mental disorders inducible mrna expression protein binding

Expression of glucocorticoid inducible genes is associated with reductions in cornu ammonis and dentate gyrus volumes in patients with major depressive disorder. (2014)

Abstract Alterations of the glucocorticoid system and of hippocampal volumes have consistently been reported in patients with major depressive disorders (MDD). The aim of the present study was to investigate whether the messenger RNA (mRNA) expression of glucocorticoid inducible genes is associated with changes in the cornu ammonis (CA) and dentate gyrus subfields. Forty-three patients with MDD and 43 healthy controls were recruited and investigated with high resolution magnetic resonance imaging. Hippocampal subfields were measured using freesurfer. Measurement of whole blood mRNA expression of glucocorticoid inducible genes serum and glucocorticoid-regulated kinase 1 (SGK1), FK506 binding protein 5 (FKBP5), and glucocorticoid induced leucine zipper (GILZ) was performed. Patients with MDD had significantly smaller volumes of CA1, CA2/3, CA4/DG, and subiculum compared to healthy controls. In the regression analysis, the factor diagnosis had a significant moderating effect on the association of SGK1 and hippocampal volumes. Patients with low expression of SGK1 had significantly smaller CA2/3 and CA4/DG volumes compared to patients with high expression of SGK1 mRNA and to healthy controls with low/high expression of SGK1, respectively. Therefore, a lack of mRNA expression of glucocorticoid inducible genes in patients with MDD that seems to correspond to a blunted cortisol response is associated with smaller hippocampal CA and dentate gyrus volumes. SGK1 seems to be particularly relevant for stress-related mental disorders.
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Full list of authors on original publication

Thomas Connor, Andrew Harkin, Martina Mary Hughes, Michael Gill, Derrek Morris, Norbert Skokauskas, Veronica O'Keane, Eva-Maria Frey, Angela Carballedo, Thomas Frodl

Experts in our system

1
Thomas Joseph Connor
Trinity College Dublin
Total Publications: 13
 
2
Andrew Harkin
Trinity College Dublin
Total Publications: 8
 
3
Martina M Hughes
Trinity College Dublin
Total Publications: 3
 
4
Michael Gill
Trinity College Dublin
Total Publications: 260
 
5
Derrek Morris
Trinity College Dublin
Total Publications: 4
 
6
Norbert Skokauskas
Trinity College Dublin
Total Publications: 12
 
7
Veronica O'Keane
Trinity College Dublin
Total Publications: 15
 
8
Eva-Maria Frey
Trinity College Dublin
Total Publications: 5
 
9
Angela Carballedo
Trinity College Dublin
Total Publications: 23
 
10
Thomas Frodl
Trinity College Dublin
Total Publications: 58