Type

Journal Article

Authors

T Bourgeron
G Schumann
A Ströhle
M N Smolka
T Robbins
M Rietschel
Z Pausova
T Paus
F Nees
K Mann
and 20 others

Subjects

Biology

Topics
body size imagen human mri imaging techniques single nucleotide polymorphisms diversity brain genomic magnetic resonance imaging mri body height architecture human genetics neuroscience

Genomic architecture of human neuroanatomical diversity. (2014)

Abstract Human brain anatomy is strikingly diverse and highly inheritable: genetic factors may explain up to 80% of its variability. Prior studies have tried to detect genetic variants with a large effect on neuroanatomical diversity, but those currently identified account for <5% of the variance. Here, based on our analyses of neuroimaging and whole-genome genotyping data from 1765 subjects, we show that up to 54% of this heritability is captured by large numbers of single-nucleotide polymorphisms of small-effect spread throughout the genome, especially within genes and close regulatory regions. The genetic bases of neuroanatomical diversity appear to be relatively independent of those of body size (height), but shared with those of verbal intelligence scores. The study of this genomic architecture should help us better understand brain evolution and disease.Molecular Psychiatry advance online publication, 16 September 2014; doi:10.1038/mp.2014.99.
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Full list of authors on original publication

T Bourgeron, G Schumann, A Ströhle, M N Smolka, T Robbins, M Rietschel, Z Pausova, T Paus, F Nees, K Mann and 20 others

Experts in our system

1
Gunter Schumann
Trinity College Dublin
Total Publications: 55
 
2
Michael N Smolka
Trinity College Dublin
Total Publications: 56
 
3
Trevor W Robbins
Trinity College Dublin
Total Publications: 24
 
4
Marcella Rietschel
Trinity College Dublin
Total Publications: 39
 
5
Tomas Paus
Trinity College Dublin
Total Publications: 56
 
6
Frauke Nees
Trinity College Dublin
Total Publications: 53