Journal Article


Deirdre McNamara
Colm O'Morain
Sinead M Smith



antimicrobial susceptibility helicobacter pylori lymphoid tissue antibiotic resistance this review material culture antimicrobial resistance pylori infection

Antimicrobial susceptibility testing for Helicobacter pylori in times of increasing antibiotic resistance. (2013)

Abstract The gram-negative bacterium Helicobacter pylori (H. pylori) causes chronic gastritis, gastric and duodenal ulcers, gastric cancer and mucosa-associated lymphoid tissue lymphoma. Treatment is recommended in all symptomatic patients. The current treatment options for H. pylori infection are outlined in this review in light of the recent challenges in eradication success, largely due to the rapid emergence of antibiotic resistant strains of H. pylori. Antibiotic resistance is a constantly evolving process and numerous studies have shown that the prevalence of H. pylori antibiotic resistance varies significantly from country to country, and even between regions within the same country. In addition, recent data has shown that previous antibiotic use is associated with harbouring antibiotic resistant H. pylori. Local surveillance of antibiotic resistance is warranted to guide clinicians in their choice of therapy. Antimicrobial resistance is assessed by H. pylori culture and antimicrobial susceptibility testing. Recently developed molecular tests offer an attractive alternative to culture and allow for the rapid molecular genetic identification of H. pylori and resistance-associated mutations directly from biopsy samples or bacterial culture material. Accumulating evidence indicates that surveillance of antimicrobial resistance by susceptibility testing is feasible and necessary to inform clinicians in their choice of therapy for management of H. pylori infection.
Collections Ireland -> Trinity College Dublin -> PubMed

Full list of authors on original publication

Deirdre McNamara, Colm O'Morain, Sinead M Smith

Experts in our system

Deirdre McNamara
TU Dublin (Tallaght Campus)
Total Publications: 51
Colm O'Morain
TU Dublin (Tallaght Campus)
Total Publications: 82
Sinead Smith
Trinity College Dublin
Total Publications: 36