Type

Journal Article

Authors

Marek W Radomski
Giuliano Elia
Gail M Annich
Yurii K Gun'ko
Kieran J Wynne
Terry C Major
Amro Satti
Maria J Santos-Martinez
Alan M Gaffney

Subjects

Biology

Topics
biocompatibility extracorporeal circulation blood polyvinyl chloride animal model multi walled carbon nanotubes platelet activation surface

Blood biocompatibility of surface-bound multi-walled carbon nanotubes. (2014)

Abstract Blood clots when it contacts foreign surfaces following platelet activation. This can be catastrophic in clinical settings involving extracorporeal circulation such as during heart-lung bypass where blood is circulated in polyvinyl chloride tubing. Studies have shown, however, that surface-bound carbon nanotubes may prevent platelet activation, the initiator of thrombosis. We studied the blood biocompatibility of polyvinyl chloride, surface-modified with multi-walled carbon nanotubes in vitro and in vivo. Our results show that surface-bound multi-walled carbon nanotubes cause platelet activation in vitro and devastating thrombosis in an in vivo animal model of extracorporeal circulation. The mechanism of the pro-thrombotic effect likely involves direct multi-walled carbon nanotube-platelet interaction with Ca(2+)-dependant platelet activation. These experiments provide evidence, for the first time, that modification of surfaces with nanomaterials modulates blood biocompatibility in extracorporeal circulation. In this study, the blood biocompatibility of polyvinyl chloride, surface-modified with multi-walled carbon nanotubes was investigated both in vitro and in vivo, showing that surface-bound multi-walled carbon nanotubes cause platelet activation in vitro, and devastating thrombosis in an in vivo animal model of extracorporeal circulation.
Collections Ireland -> Trinity College Dublin -> PubMed

Full list of authors on original publication

Marek W Radomski, Giuliano Elia, Gail M Annich, Yurii K Gun'ko, Kieran J Wynne, Terry C Major, Amro Satti, Maria J Santos-Martinez, Alan M Gaffney

Experts in our system

1
Marek W Radomski
Trinity College Dublin
Total Publications: 44
 
2
Yurii K Gun'ko
Trinity College Dublin
Total Publications: 49
 
3
Kieran Wynne
Royal College of Surgeons in Ireland
Total Publications: 45
 
4
Maria Jose Santos-Martinez
Trinity College Dublin
Total Publications: 29