Type

Journal Article

Authors

Aiden Corvin
Louise Gallagher
Michael Gill
Heike Anderson-Schmidt
April Hargreaves
Eric Kelleher
Susan Moore
Richard J L Anney
Elizabeth A Heron
Paul Cormican
and 2 others

Subjects

Psychiatry

Topics
family history psychology mental illness risk factors rare cognitive function schizophrenia irish paternal age

The phenotypic manifestations of rare CNVs in schizophrenia. (2014)

Abstract There is compelling evidence for the role of copy number variants (CNVs) in schizophrenia susceptibility, and it has been estimated that up to 2-3% of schizophrenia cases may carry rare CNVs. Despite evidence that these events are associated with an increased risk across categorical neurodevelopmental disorders, there is limited understanding of the impact of CNVs on the core features of disorders like schizophrenia. Our objective was to evaluate associations between rare CNVs in differentially brain expressed (BE) genes and the core features and clinical correlates of schizophrenia. The sample included 386 cases of Irish ancestry with a diagnosis of schizophrenia, at least one rare CNV impacting any gene, and a core set of phenotypic measures. Statistically significant associations between deletions in differentially BE genes were found for family history of mental illness (decreased prevalence of all CNVs and deletions, unadjusted and adjusted) and for paternal age (increase in deletions only, unadjusted, among those with later ages at birth of patient). The strong effect of a lack of a family history on BE genes suggests that CNVs may comprise one pathway to schizophrenia, whereas a positive family history could index other genetic mechanisms that increase schizophrenia vulnerability. To our knowledge, this is the first investigation of the association between genome-wide CNVs and risk factors and sub-phenotypic features of schizophrenia beyond cognitive function.
Collections Ireland -> National College Ireland -> Status = Published
Ireland -> National College Ireland -> Subject = B Philosophy. Psychology. Religion
Ireland -> Trinity College Dublin -> PubMed
Ireland -> National College of Ireland -> Type = Article
Ireland -> National College Ireland -> Subject = B Philosophy. Psychology. Religion: Psychology
Ireland -> National College of Ireland -> Status = Published
Ireland -> National College of Ireland -> Subject = B Philosophy. Psychology. Religion
Ireland -> National College of Ireland -> Subject = B Philosophy. Psychology. Religion: Psychology
Ireland -> National College Ireland -> Type = Article

Full list of authors on original publication

Aiden Corvin, Louise Gallagher, Michael Gill, Heike Anderson-Schmidt, April Hargreaves, Eric Kelleher, Susan Moore, Richard J L Anney, Elizabeth A Heron, Paul Cormican and 2 others

Experts in our system

1
Aiden Corvin
Trinity College Dublin
Total Publications: 190
 
2
Louise Gallagher
Trinity College Dublin
Total Publications: 55
 
3
Michael Gill
Trinity College Dublin
Total Publications: 260
 
4
Heike Anderson-Schmidt
National University of Ireland Galway
Total Publications: 7
 
5
April Hargreaves
Trinity College Dublin
Total Publications: 27
 
6
Eric Kelleher
Trinity College Dublin
Total Publications: 4
 
7
Susan Moore
Trinity College Dublin
Total Publications: 6
 
8
Richard Anney
Trinity College Dublin
Total Publications: 38
 
9
Elizabeth Heron
Trinity College Dublin
Total Publications: 14
 
10
Paul Cormican
Trinity College Dublin
Total Publications: 39