Type

Journal Article

Authors

Gunter Schumann
Sukhwinder S Shergill
Michael N Smolka
Trevor Robbins
Marcella Rietschel
Zdenka Pausova
Tomáš Paus
Frauke Nees
Marie-Laure Paillère
Karl Mann
and 19 others

Subjects

Psychiatry

Topics
inhibitory control frontal cortex comt adolescence blood sex reaction time polymorphism

Sex differences in COMT polymorphism effects on prefrontal inhibitory control in adolescence. (2013)

Abstract Catecholamine-0-methyl-transferase (COMT) gene variation effects on prefrontal blood oxygenation-level-dependent (BOLD) activation are robust; however, despite observations that COMT is estrogenically catabolized, sex differences in its prefrontal repercussions remain unclear. Here, in a large sample of healthy adolescents stratified by sex and Val(158)Met genotype (n=1133), we examine BOLD responses during performance of the stop-signal task in right-hemispheric prefrontal regions fundamental to inhibitory control. A significant sex-by-genotype interaction was observed in pre-SMA during successful-inhibition trials and in both pre-SMA and inferior frontal cortex during failed-inhibition trials with Val homozygotes displaying elevated activation compared with other genotypes in males but not in females. BOLD activation in the same regions significantly mediated the relationship between COMT genotype and inhibitory proficiency as indexed by stop-signal reaction time in males alone. These sexually dimorphic effects of COMT on inhibitory brain activation have important implications for our understanding of the contrasting patterns of prefrontally governed psychopathology observed in males and females.
Collections Ireland -> Trinity College Dublin -> PubMed

Full list of authors on original publication

Gunter Schumann, Sukhwinder S Shergill, Michael N Smolka, Trevor Robbins, Marcella Rietschel, Zdenka Pausova, Tomáš Paus, Frauke Nees, Marie-Laure Paillère, Karl Mann and 19 others

Experts in our system

1
Gunter Schumann
Trinity College Dublin
Total Publications: 55
 
2
Michael N Smolka
Trinity College Dublin
Total Publications: 56
 
3
Trevor W Robbins
Trinity College Dublin
Total Publications: 24
 
4
Marcella Rietschel
Trinity College Dublin
Total Publications: 39
 
5
Tomas Paus
Trinity College Dublin
Total Publications: 56
 
6
Frauke Nees
Trinity College Dublin
Total Publications: 53