Journal Article


G Schumann
J Feng
T Paus
Z Pausova
M N Smolka
M Fauth-Bühler
P Thompson
M Rietschel
J-B Poline
M Lathrop
and 27 others



cell line stem cell association study individual differences single nucleotide polymorphisms snps large scale children and adolescents cell adhesion

Single nucleotide polymorphism in the neuroplastin locus associates with cortical thickness and intellectual ability in adolescents. (2013)

Abstract Despite the recognition that cortical thickness is heritable and correlates with intellectual ability in children and adolescents, the genes contributing to individual differences in these traits remain unknown. We conducted a large-scale association study in 1583 adolescents to identify genes affecting cortical thickness. Single-nucleotide polymorphisms (SNPs; n=54 837) within genes whose expression changed between stages of growth and differentiation of a human neural stem cell line were selected for association analyses with average cortical thickness. We identified a variant, rs7171755, associating with thinner cortex in the left hemisphere (P=1.12 × 10(-)(7)), particularly in the frontal and temporal lobes. Localized effects of this SNP on cortical thickness differently affected verbal and nonverbal intellectual abilities. The rs7171755 polymorphism acted in cis to affect expression in the human brain of the synaptic cell adhesion glycoprotein-encoding gene NPTN. We also found that cortical thickness and NPTN expression were on average higher in the right hemisphere, suggesting that asymmetric NPTN expression may render the left hemisphere more sensitive to the effects of NPTN mutations, accounting for the lateralized effect of rs7171755 found in our study. Altogether, our findings support a potential role for regional synaptic dysfunctions in forms of intellectual deficits.Molecular Psychiatry advance online publication, 11 February 2014; doi:10.1038/mp.2013.197.
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Full list of authors on original publication

G Schumann, J Feng, T Paus, Z Pausova, M N Smolka, M Fauth-Bühler, P Thompson, M Rietschel, J-B Poline, M Lathrop and 27 others

Experts in our system

Gunter Schumann
Trinity College Dublin
Total Publications: 65
Tomas Paus
Trinity College Dublin
Total Publications: 62
Michael N Smolka
Trinity College Dublin
Total Publications: 65
Paul M Thompson
Trinity College Dublin
Total Publications: 23
Marcella Rietschel
Trinity College Dublin
Total Publications: 40