Journal Article


Adrian Danek
Helmut Heinsen
Anne Ebert
Christina Knels
Eduardo Alho
Vanja Kljajevic
Edson Amaro
Lea Grinberg
Arun L W Bokde
Ingo Kilimann
and 4 others



magnetic resonance imaging mri progressive high resolution brain temporal lobe primary atrophy post mortem

Brain atrophy in primary progressive aphasia involves the cholinergic basal forebrain and Ayala's nucleus. (2013)

Abstract Primary progressive aphasia (PPA) is characterized by left hemispheric frontotemporal cortical atrophy. Evidence from anatomical studies suggests that the nucleus subputaminalis (NSP), a subnucleus of the cholinergic basal forebrain, may be involved in the pathological process of PPA. Therefore, we studied the pattern of cortical and basal forebrain atrophy in 10 patients with a clinical diagnosis of PPA and 18 healthy age-matched controls using high-resolution magnetic resonance imaging (MRI). We determined the cholinergic basal forebrain nuclei according to Mesulam's nomenclature and the NSP in MRI reference space based on histological sections and the MRI scan of a post-mortem brain in cranio. Using voxel-based analysis, we found left hemispheric cortical atrophy in PPA patients compared with controls, including prefrontal, lateral temporal and medial temporal lobe areas. We detected cholinergic basal forebrain atrophy in left predominant localizations of Ch4p, Ch4am, Ch4al, Ch3 and NSP. For the first time, we have described the pattern of basal forebrain atrophy in PPA and confirmed the involvement of NSP that had been predicted based on theoretical considerations. Our findings may enhance understanding of the role of cholinergic degeneration for the regional specificity of the cortical destruction leading to the syndrome of PPA.
Collections Ireland -> Trinity College Dublin -> PubMed

Full list of authors on original publication

Adrian Danek, Helmut Heinsen, Anne Ebert, Christina Knels, Eduardo Alho, Vanja Kljajevic, Edson Amaro, Lea Grinberg, Arun L W Bokde, Ingo Kilimann and 4 others

Experts in our system

Arun L W Bokde
Trinity College Dublin
Total Publications: 144