Type

Journal Article

Authors

Andrew Simmons
Simon Lovestone
Gunther Schumann
Eric Westman
Jean Gallinat
Andreas Ströhle
Michael N Smolka
Marcella Rietschel
Zdenka Pausova
Tomáš Paus
and 20 others

Subjects

Medicine & Nursing

Topics
genetics humans cohort studies male hippocampus apolipoprotein e4 adolescent magnetic resonance imaging anatomy histology apolipoproteins e female

No differences in hippocampal volume between carriers and non-carriers of the ApoE ε4 and ε2 alleles in young healthy adolescents. (2013)

Abstract Alleles of the apolipoprotein E (ApoE) gene are known to modulate the genetic risk for developing late-onset Alzheimer's disease (AD) and have been associated with hippocampal volume differences in AD. However, the effect of these alleles on hippocampal volume in younger subjects has yet to be clearly established. Using a large cohort of more than 1,400 adolescents, this study found no hippocampal volume or hippocampal asymmetry differences between carriers and non-carriers of the ApoE ε4 or ε2 alleles, nor dose-dependent effects of either allele, suggesting that regionally specific effects of these polymorphisms may only become apparent in later life.
Collections Ireland -> Trinity College Dublin -> PubMed

Full list of authors on original publication

Andrew Simmons, Simon Lovestone, Gunther Schumann, Eric Westman, Jean Gallinat, Andreas Ströhle, Michael N Smolka, Marcella Rietschel, Zdenka Pausova, Tomáš Paus and 20 others

Experts in our system

1
Andrew Simmons
Royal College of Surgeons in Ireland
Total Publications: 6
 
2
Simon Lovestone
Royal College of Surgeons in Ireland
Total Publications: 6
 
3
Michael N Smolka
Trinity College Dublin
Total Publications: 56
 
4
Marcella Rietschel
Trinity College Dublin
Total Publications: 39
 
5
Tomas Paus
Trinity College Dublin
Total Publications: 56