Type

Journal Article

Authors

Bertrand Thirion
Jean-Baptiste Poline
Vincent Frouin
Andreas Ströhle
Michael N Smolka
Marcella Rietschel
Zdenka Pausova
Tomáš Paus
Frauke Nees
Jean-Luc Martinot
and 10 others

Subjects

Psychiatry

Topics
higher genetic state of the art stability inference functional magnetic resonance imaging randomized brain diseases

Randomized parcellation based inference. (2013)

Abstract Neuroimaging group analyses are used to relate inter-subject signal differences observed in brain imaging with behavioral or genetic variables and to assess risks factors of brain diseases. The lack of stability and of sensitivity of current voxel-based analysis schemes may however lead to non-reproducible results. We introduce a new approach to overcome the limitations of standard methods, in which active voxels are detected according to a consensus on several random parcellations of the brain images, while a permutation test controls the false positive risk. Both on synthetic and real data, this approach shows higher sensitivity, better accuracy and higher reproducibility than state-of-the-art methods. In a neuroimaging-genetic application, we find that it succeeds in detecting a significant association between a genetic variant next to the COMT gene and the BOLD signal in the left thalamus for a functional Magnetic Resonance Imaging contrast associated with incorrect responses of the subjects from a Stop Signal Task protocol.
Collections Ireland -> Trinity College Dublin -> PubMed

Full list of authors on original publication

Bertrand Thirion, Jean-Baptiste Poline, Vincent Frouin, Andreas Ströhle, Michael N Smolka, Marcella Rietschel, Zdenka Pausova, Tomáš Paus, Frauke Nees, Jean-Luc Martinot and 10 others

Experts in our system

1
Vincent Frouin
Trinity College Dublin
Total Publications: 55
 
2
Michael N Smolka
Trinity College Dublin
Total Publications: 65
 
3
Marcella Rietschel
Trinity College Dublin
Total Publications: 40
 
4
Tomas Paus
Trinity College Dublin
Total Publications: 62
 
5
Frauke Nees
Trinity College Dublin
Total Publications: 63
 
6
Jean-Luc Martinot
Trinity College Dublin
Total Publications: 54