Type

Journal Article

Authors

Thomas Frodl
James Meaney
Norbert Skokauskas
Andrew Fagan
Francesco Amico
Angela Carballedo
Aisling Chaney

Subjects

Psychiatry

Topics
magnetic resonance imaging mri childhood maltreatment prefrontal cortex voxel based morphometry major depressive disorder mdd high resolution early childhood sample size

Effect of childhood maltreatment on brain structure in adult patients with major depressive disorder and healthy participants. (2013)

Abstract Background: Childhood maltreatment has been found to play a crucial role in the development of psychiatric disorders. However, whether childhood maltreatment is associated with structural brain changes described for major depressive disorder (MDD) is still a matter of debate. The aim of this study was to investigate whether patients with MDD and a history of childhood maltreatment display more structural changes than patients without childhood maltreatment or healthy controls. Methods: Patients with MDD and healthy controls with and without childhood maltreatment experience were investigated using high-resolution magnetic resonance imaging (MRI), and data were analyzed using voxel-based morphometry. Results: We studied 37 patients with MDD and 46 controls. Grey matter volume was significantly decreased in the hippocampus and significantly increased in the dorsomedial prefrontal cortex (DMPFC) and the orbitofrontal cortex (OFC) in participants who had experienced childhood maltreatment compared with those who had not. Patients displayed smaller left OFC and left DMPFC volumes than controls. No significant difference in hippocampal volume was evident between patients with MDD and healthy controls. In regression analyses, despite effects from depression, age and sex on the DMPFC, OFC and hippocampus, childhood maltreatment was found to independently affect these regions. Limitations: The retrospective assessment of childhood maltreatment; the natural problem that patients experienced more childhood maltreatment than controls; and the restrictions, owing to sample size, to investigating higher order interactions among factors are discussed as limitations. Conclusion: These results suggest that early childhood maltreatment is associated with brain structural changes irrespective of sex, age and a history of depression. Thus, the study highlights the importance of childhood maltreatment when investigating brain structures.
Collections Ireland -> Trinity College Dublin -> PubMed

Full list of authors on original publication

Thomas Frodl, James Meaney, Norbert Skokauskas, Andrew Fagan, Francesco Amico, Angela Carballedo, Aisling Chaney

Experts in our system

1
Thomas Frodl
Trinity College Dublin
Total Publications: 58
 
2
James Meaney
Trinity College Dublin
Total Publications: 28
 
3
Norbert Skokauskas
Trinity College Dublin
Total Publications: 12
 
4
Andrew John Fagan
Trinity College Dublin
Total Publications: 72
 
5
Francesco Amico
Trinity College Dublin
Total Publications: 8
 
6
Angela Carballedo
Trinity College Dublin
Total Publications: 23