Journal Article


Stefan Teipel
Harald Hampel
Thomas Meindl
Andreas Fellgiebel
Arun L W Bokde
Elisabeth Kasper
Martin Dyrba
Carsten Holzmann
Peter Meyer
Vanja Kljajevic


Medicine & Nursing

pathology apolipoprotein e4 diffusion magnetic resonance imaging anisotropy male brain diffusion tensor imaging aged 80 and over humans middle aged alzheimer disease aged white matter genotype heterozygote female genetics

The ε4 genotype of apolipoprotein E and white matter integrity in Alzheimer's disease. (2012)

Abstract In this multicenter study, we investigated a possible association between the APOE ε4 allele and white matter (WM) integrity in Alzheimer's disease (AD) using diffusion tensor imaging (DTI). We analyzed fractional anisotropy (FA) and mean diffusivity (MD) as indices of WM integrity in 70 AD patients (35 APOE ε4 carriers, 35 noncarriers) and 56 healthy control (HC) subjects (28 APOE ε4 carriers, 28 noncarriers). APOE ε4 carriers and noncarriers were matched for age and gender within each diagnostic group. We found significant effects of diagnosis (Pcorrected < .05 [FWE]; i.e., smaller FA values and larger MD values in AD patients compared with HCs) and significant effects (P < .001) of APOE ε4 carrier status on MD in HCs but not in AD subjects. The results indicate that APOE ε4 has a moderate effect on WM integrity in HCs, but no effect on WM integrity in manifest AD.
Collections Ireland -> Trinity College Dublin -> PubMed

Full list of authors on original publication

Stefan Teipel, Harald Hampel, Thomas Meindl, Andreas Fellgiebel, Arun L W Bokde, Elisabeth Kasper, Martin Dyrba, Carsten Holzmann, Peter Meyer, Vanja Kljajevic

Experts in our system

Stefan J Teipel
Trinity College Dublin
Total Publications: 12
Harald Hampel
Trinity College Dublin
Total Publications: 35
Arun L W Bokde
Trinity College Dublin
Total Publications: 144