Type

Journal Article

Authors

Ian H Robertson
Neil Upton
Robert Lai
Arun L W Bokde
Sophia M Kilcullen
Eleanora Greco
Hugh Nolan
Alessandra Galli
Redmond G O'Connell
Joshua Henk Balsters

Subjects

Psychiatry

Topics
age brain default mode networks functional connectivity blood functional magnetic resonance imaging electroencephalogram

Changes in resting connectivity with age: a simultaneous electroencephalogram and functional magnetic resonance imaging investigation. (2012)

Abstract Resting fluctuations in the blood oxygenation level-dependent signal have attracted considerable interest for their sensitivity to pathological brain processes. However, these analyses are susceptible to confound by nonneural physiological factors such as vasculature, breathing, and head movement which is a concern when investigating elderly or pathological groups. Here, we used simultaneous electroencephalogram (EEG) and functional magnetic resonance imaging (fMRI) (EEG/fMRI) to constrain the analysis of resting state networks (RSNs) and identify aging differences. Four of 26 RSNs showed fMRI and EEG/fMRI group differences; anterior default-mode network, left frontal-parietal network, bilateral middle frontal, and postcentral gyri. Seven RSNs showed only EEG/fMRI differences suggesting the combination of these 2 methods might be more sensitive to age-related neural changes than fMRI alone. Five RSNs showed only fMRI differences and might reflect nonneural group differences. Activity within some EEG/fMRI RSNs was better explained by neuropsychological measures (Mini Mental State Examination and Stroop) than age. These results support previous studies suggesting that age-related changes in specific RSNs are neural in origin, and show that changes in some RSNs relate better to elderly cognition than age.
Collections Ireland -> Trinity College Dublin -> PubMed

Full list of authors on original publication

Ian H Robertson, Neil Upton, Robert Lai, Arun L W Bokde, Sophia M Kilcullen, Eleanora Greco, Hugh Nolan, Alessandra Galli, Redmond G O'Connell, Joshua Henk Balsters

Experts in our system

1
Ian H Robertson
Trinity College Dublin
Total Publications: 142
 
2
Arun L W Bokde
Trinity College Dublin
Total Publications: 76
 
3
Hugh Nolan
Trinity College Dublin
Total Publications: 17
 
4
Redmond G O'Connell
Trinity College Dublin
Total Publications: 49
 
5
Joshua Balsters
Trinity College Dublin
Total Publications: 23