Type

Journal Article

Authors

A Harkin
C M Kerskens
C W Blau
M E Kelly
D Byrne
B Behan
P Duffy
K McHugh Smith
I Ogden
V Gigliucci
and 3 others

Subjects

Psychiatry

Topics
drug use mri 7t mri motor cortex somatosensory cortex experimental data h 3 tracking

MDMA 'ecstasy' increases cerebral cortical perfusion determined by bolus-tracking arterial spin labelling (btASL) MRI. (2012)

Abstract The purpose of this study was to assess cerebral perfusion changes following systemic administration of the recreational drug 3,4-methylendioxymethamphetamine (MDMA 'ecstasy') to rats. Cerebral perfusion was quantified using bolus-tracking arterial spin labelling (btASL) MRI. Rats received MDMA (20 mg·kg(-1); i.p.) and were assessed 1, 3 or 24 h later. Rats received MDMA (5 or 20 mg·kg(-1); i.p.) and were assessed 3 h later. In addition, rats received MDMA (5 or 10 mg·kg(-1); i.p.) or saline four times daily over 2 consecutive days and were assessed 8 weeks later. Perfusion-weighted images were generated in a 7 tesla (7T) MRI scanner and experimental data was fitted to a quantitative model of cerebral perfusion to generate mean transit time (MTT), capillary transit time (CTT) and signal amplitude. MDMA reduces MTT and CTT and increases amplitude in somatosensory and motor cortex 1 and 3 h following administration, indicative of an increase in perfusion. Prior exposure to MDMA provoked a long-term reduction in cortical 5-HT concentration, but did not produce a sustained effect on cerebral cortical perfusion. The response to acute MDMA challenge (20 mg·kg(-1); i.p.) was attenuated in these animals indicating adaptation in response to prior MDMA exposure. MDMA provokes changes in cortical perfusion, which are quantifiable by btASL MRI, a neuroimaging tool with translational potential. Future studies are directed towards elucidation of the mechanisms involved and correlating changes in cerebrovascular function with potential behavioural deficits associated with drug use.
Collections Ireland -> Trinity College Dublin -> PubMed

Full list of authors on original publication

A Harkin, C M Kerskens, C W Blau, M E Kelly, D Byrne, B Behan, P Duffy, K McHugh Smith, I Ogden, V Gigliucci and 3 others

Experts in our system

1
Andrew Harkin
Trinity College Dublin
Total Publications: 28
 
2
Christian Kerskens
Trinity College Dublin
Total Publications: 26
 
3
Michelle E Kelly
National College Ireland
Total Publications: 51