Type

Journal Article

Authors

Thomas Frodl
Hans-Jürgen Möller
Michael Gill
Brigitta Bondy
Eva Meisenzahl
Elena Reinhold
Ciara Fahey
Peter Zill
Derek Morris
Angela Carballedo

Subjects

Psychiatry

Topics
major depressive disorder mdd life events childhood trauma brain derived neurotrophic factor childhood adversity brain derived neurotrophic factor bdnf magnetic resonance imaging high resolution

Brain-derived neurotrophic factor Val66Met polymorphism and early life adversity affect hippocampal volume. (2012)

Abstract The interaction between adverse life events during childhood and genetic factors is associated with a higher risk to develop major depressive disorder (MDD). One of the polymorphisms found to be associated with MDD is the Val66MET polymorphism of brain-derived neurotrophic factor (BDNF). The aim of our two-center study was to determine how the BDNF Val66Met polymorphism and childhood adversity affect the volumetric measures of the hippocampus in healthy individuals and people with MDD. In this two-center study, 62 adult patients with MDD and 71 healthy matched controls underwent high-resolution magnetic resonance imaging. We used manual tracing of the bilateral hippocampal structure with help of the software BRAINS2, assessed childhood adversity using the Childhood Trauma Questionnaire and genotyped Val66Met BDNF SNP (rs6265). MDD patients had smaller hippocampal volumes, both in the left and right hemispheres (F = 5.4, P = 0.022). We also found a significant interaction between BDNF allele and history of childhood adversity (F = 6.1, P = 0.015): Met allele carriers in our samples showed significantly smaller hippocampal volumes when they did have a history of childhood adversity, both in patients and controls. Our results highlight how relevant stress-gene interactions are for hippocampal volume reductions. Subjects exposed to early life adversity developed smaller hippocampal volumes when they carry the Met-allele of the BDNF polymorphism. © 2013 Wiley Periodicals, Inc.
Collections Ireland -> Trinity College Dublin -> PubMed

Full list of authors on original publication

Thomas Frodl, Hans-Jürgen Möller, Michael Gill, Brigitta Bondy, Eva Meisenzahl, Elena Reinhold, Ciara Fahey, Peter Zill, Derek Morris, Angela Carballedo

Experts in our system

1
Thomas Frodl
Trinity College Dublin
Total Publications: 58
 
2
Hans-Jürgen Möller
Trinity College Dublin
Total Publications: 6
 
3
Michael Gill
Trinity College Dublin
Total Publications: 260
 
4
Eva M Meisenzahl
Trinity College Dublin
Total Publications: 4
 
5
Ciara Fahey
Trinity College Dublin
Total Publications: 30
 
6
Derek Morris
Trinity College Dublin
Total Publications: 150
 
7
Angela Carballedo
Trinity College Dublin
Total Publications: 23