Type

Journal Article

Authors

Orla Hardiman
Niall Pender
Andrew J Fagan
Catherine Lynch
Laura Gallagher
Harald Hampel
Norah Jordan
Russell L McLaughlin
Susan Byrne
Marwa Elamin
and 2 others

Subjects

Psychiatry

Topics
clinical study motor cortex amyotrophic lateral sclerosis neuroimaging heterogeneity phenotype grey matter body regions

Grey matter correlates of clinical variables in amyotrophic lateral sclerosis (ALS): a neuroimaging study of ALS motor phenotype heterogeneity and cortical focality. (2012)

Abstract BACKGROUND: Body region of onset and functional disability are key components of disease heterogeneity in amyotrophic lateral sclerosis (ALS). OBJECTIVES: To evaluate patterns of grey matter pathology in the motor cortex and correlate focal structural changes with functional disability. METHODS: We conducted a single-centre neuroimaging study of a cohort of 33 cognitively normal patients with amyotrophic lateral sclerosis (ALS) and 44 healthy controls. A voxel-wise generalised linear model was used to investigate the distribution of disease burden within the motor cortex in relation to clinical disability. RESULTS: Patients with bulbar onset have bilateral focal atrophy in the bulbar segment of the motor homunculus compared with patients with limb onset who have focal cortical changes in the limb segment of their motor strip. Furthermore, the extent to which different body regions are affected in ALS corresponds to the extent of focal grey matter loss in the primary motor cortex. Cortical ALS pathology also extends beyond the motor cortex affecting frontal, occipital and temporal regions. CONCLUSIONS: Focal grey matter atrophy within the motor homunculus corresponds with functional disability in ALS. The findings support the existing concepts of cortical focality and motor phenotype heterogeneity in ALS.
Collections Ireland -> Trinity College Dublin -> PubMed

Full list of authors on original publication

Orla Hardiman, Niall Pender, Andrew J Fagan, Catherine Lynch, Laura Gallagher, Harald Hampel, Norah Jordan, Russell L McLaughlin, Susan Byrne, Marwa Elamin and 2 others

Experts in our system

1
Orla Hardiman
Trinity College Dublin
Total Publications: 156
 
2
Niall Pender
Trinity College Dublin
Total Publications: 30
 
3
Andrew John Fagan
Trinity College Dublin
Total Publications: 79
 
4
Harald Hampel
Trinity College Dublin
Total Publications: 35
 
5
Russell L McLaughlin
Trinity College Dublin
Total Publications: 41
 
6
Susan Byrne
Trinity College Dublin
Total Publications: 18
 
7
Marwa Elamin
Trinity College Dublin
Total Publications: 22