Journal Article


A Corvin
M Gill
D W Morris
K C Murphy
J L Waddington
F A O'Neill
E O'Callaghan
C McDonald
T G Dinan
C Fahey
and 4 others



novel the genome wide association schizophrenia bipolar disorder cognitive specific mood psychotic symptoms

Mood congruent psychotic symptoms and specific cognitive deficits in carriers of the novel schizophrenia risk variant at MIR-137. (2012)

Abstract The Schizophrenia Psychiatric Genome-wide Association (GWAS) Consortium recently reported on five novel schizophrenia susceptibility loci. The most significant finding mapped to a micro-RNA, MIR-137, which may be involved in regulating the function of other schizophrenia and bipolar disorder susceptibility genes. We genotyped 821 patients with confirmed DSM-IV diagnoses of schizophrenia, bipolar affective disorder I and schizoaffective disorder for the risk SNP (rs1625579) and investigated the clinical profiles of risk allele carriers using a within-case design. We also assessed neurocognitive performance in a subset of cases (n=399) and controls (n=171). Carriers of the risk allele had lower scores for an OPCRIT-derived positive symptom factor (p=0.04) and lower scores on a lifetime measure of psychosis incongruity (p=0.017). Risk allele carriers also had more cognitive deficits involving episodic memory and attentional control. This is the first evidence that the MIR-137 risk variant may be associated with a specific subgroup of psychosis patients. Although the effect of this single SNP was not clinically relevant, investigation of the impact of carrying multiple risk SNPs in the MIR-137 regulatory network on diagnosis and illness profile may be warranted.
Collections Ireland -> Trinity College Dublin -> PubMed

Full list of authors on original publication

A Corvin, M Gill, D W Morris, K C Murphy, J L Waddington, F A O'Neill, E O'Callaghan, C McDonald, T G Dinan, C Fahey and 4 others

Experts in our system

Aiden Corvin
Trinity College Dublin
Total Publications: 199
Michael Gill
Trinity College Dublin
Total Publications: 273
Derek Morris
Trinity College Dublin
Total Publications: 156
Kathy Murphy
National University of Ireland Galway
Total Publications: 28
John L Waddington
Royal College of Surgeons in Ireland
Total Publications: 169
Eadbhard O'Callaghan
University College Dublin
Total Publications: 39
Colm McDonald
National University of Ireland Galway
Total Publications: 45
Ciara Fahey
Trinity College Dublin
Total Publications: 30