Type

Journal Article

Authors

Thomas Frodl
Michael Gill
James Meaney
Gary Donohoe
Ciara Fahey
Derek Morris
Andrew Fagan
Danuta Lisiecka
Angela Carballedo
Rachel Bermingham

Subjects

Psychiatry

Topics
single nucleotide polymorphisms major depressive disorder mdd genome wide association study functional magnetic resonance imaging brain magnetic resonance imaging mri genetic changes emotion regulation

Effect of genetic variant in BICC1 on functional and structural brain changes in depression. (2012)

Abstract Genes and early-life adversity (ELA) interactively increase the risk of developing major depressive disorder (MDD). A recent genome-wide association study suggests that the minor T-allele of single-nucleotide polymorphisms in the bicaudal C homolog 1 gene (BICC1) has a protective role against MDD. The aims of the study were to investigate whether the minor T-allele of BICC1 is protective against hippocampal structural brain changes, whether it is associated with increased functional brain activity in the emotion regulation system, and how ELA would modify this association. Forty-four patients with MDD and 44 healthy controls were investigated using structural magnetic resonance imaging (MRI) and functional MRI with an emotion inhibition task. Analysis of a single-nucleotide polymorphism in the BICC1-1 (rs999845) gene was performed. Right hippocampal bodies of patients and controls without a history of ELA and who carry the protective T-allele of BICC1 were significantly larger compared with those participants homozygous for the major C-allele of BICC1. However, MDD patients with ELA, who carry the T-allele, had smaller hippocampal head volumes compared with MDD patients without ELA. FMRI showed that patients and controls carrying the protective T-allele of BICC1 activate the emotion regulation system significantly more compared with those participants homozygous for the major C-allele (p<0.05, family wise error corrected). These results are suggestive that the minor T-allele of BICC1 has a protective role against MDD and its known structural and functional brain changes. However, this protective effect seems to be lost in the case of co-occurrence of ELA.
Collections Ireland -> Trinity College Dublin -> PubMed

Full list of authors on original publication

Thomas Frodl, Michael Gill, James Meaney, Gary Donohoe, Ciara Fahey, Derek Morris, Andrew Fagan, Danuta Lisiecka, Angela Carballedo, Rachel Bermingham

Experts in our system

1
Thomas Frodl
Trinity College Dublin
Total Publications: 58
 
2
Michael Gill
Trinity College Dublin
Total Publications: 260
 
3
James Meaney
Trinity College Dublin
Total Publications: 25
 
4
Gary Donohoe
Trinity College Dublin
Total Publications: 130
 
5
Ciara Fahey
Trinity College Dublin
Total Publications: 30
 
6
Derek Morris
Trinity College Dublin
Total Publications: 150
 
7
Andrew John Fagan
Trinity College Dublin
Total Publications: 70
 
8
Danuta Lisiecka
Trinity College Dublin
Total Publications: 8
 
9
Angela Carballedo
Trinity College Dublin
Total Publications: 23