Journal Article


Thomas Frodl
Gerard Boyle
Gerald Connolly
Andrew J Fagan
Danutia Lisiecka
Angela Carballedo
Karim Saleh



depression family history magnetic resonance imaging mri gender history emotion regulation clinical assessment major depressive disorder mdd amygdala

Impact of family history and depression on amygdala volume. (2011)

Abstract Family history of depression significantly impacts life-long depression risk. Family history could impact the stress and emotion regulation system that involves the amygdala. This study's purpose was to investigate family history's effect on amygdala volumes, and differences in first degree relatives with and without major depressive disorder (MDD). Participants, aged 18-65, were healthy volunteers (N=52) with (n=26) and without (n=26) first degree family history, and patients with MDD (N=48) with (n=27) and without (n=21)first-degree family history recruited for structural magnetic resonance imaging (MRI). Participants underwent clinical assessment followed by manual amygdala tracing. Patients with MDD without family history showed significantly larger right amygdala without a family history of MDD. These effects had larger right amygdala than healthy controls without MDD family history. These effects were pronounced in females. Family history and gender impacted amygdala volumes in all participants, providing a rationale for the inconsistent results in MDD amygdala studies. Higher familial risk in depression seems to be associated with smaller amygdala volumes, whereas depression alone is associated with larger amygdala volumes. Ultimately, these findings highlight consideration of family history and gender in research and treatment strategies.
Collections Ireland -> Trinity College Dublin -> PubMed

Full list of authors on original publication

Thomas Frodl, Gerard Boyle, Gerald Connolly, Andrew J Fagan, Danutia Lisiecka, Angela Carballedo, Karim Saleh

Experts in our system

Thomas Frodl
Trinity College Dublin
Total Publications: 58
Gerard Boyle
Royal College of Surgeons in Ireland
Total Publications: 4
Andrew John Fagan
Trinity College Dublin
Total Publications: 72
Angela Carballedo
Trinity College Dublin
Total Publications: 23