Journal Article


T Frodl
A Leemans
J F Meaney
D Morris
C Fahey
A J Fagan
I Ugwu
F Amico
A Carballedo



diffusion tensor imaging pathology brain male alleles young adult aged case control studies anisotropy middle aged adult genetic predisposition to disease humans adolescent brain derived neurotrophic factor drug therapy female depressive disorder major polymorphism single nucleotide genetics demography

Reduced fractional anisotropy in the uncinate fasciculus in patients with major depression carrying the met-allele of the Val66Met brain-derived neurotrophic factor genotype. (2012)

Abstract Experimental studies support a neurotrophic hypothesis of major depressive disorder (MDD). The aim of this study was to determine the effect of Val66Met brain-derived neurotrophic factor (BDNF) polymorphism on the white matter fiber tracts connecting hippocampus and amygdala with the prefrontal lobe in a sample of patients with MDD and healthy controls. Thirty-seven patients with MDD and 42 healthy volunteers were recruited. Diffusion tensor imaging (DTI) data with 61 diffusion directions were obtained with MRI 3 Tesla scanner. Deterministic tractography was applied with ExploreDTI and Val66Met BDNF SNP (rs6265) was genotyped. Fiber tracts connecting the hippocampus and amygdala with the prefrontal lobe, namely uncinate fasciculus (UF), fornix, and cingulum were analyzed. A significant interaction was found in the UF between BDNF alleles and diagnosis. Patients carrying the BDNF met-allele had smaller fractional anisotropy (FA) in the UF compared to those patients homozygous for val-allele and compared to healthy subjects carrying the met-allele. A significant three-way interaction was detected between region of the cingulum (dorsal, rostral, and parahippocampal regions), brain hemisphere and BDNF genotype. Larger FA was detectable in the left rostral cingulum for met-allele carriers when compared to val/val alelle carriers. We provide evidence for the importance of the neurotrophic involvement in limbic and prefrontal connections. The met-allele of the BDNF polymorphism seems to render subjects more vulnerable for dysfunctions associated with the UF, a tract known to be related to negative emotional-cognitive processing bias, declarative memory problems, and autonoetic self awareness.
Collections Ireland -> Trinity College Dublin -> PubMed

Full list of authors on original publication

T Frodl, A Leemans, J F Meaney, D Morris, C Fahey, A J Fagan, I Ugwu, F Amico, A Carballedo

Experts in our system

Thomas Frodl
Trinity College Dublin
Total Publications: 58
Alexander Leemans
National University of Ireland Galway
Total Publications: 12
James Meaney
Trinity College Dublin
Total Publications: 28
Derek Morris
Trinity College Dublin
Total Publications: 156
Ciara Fahey
Trinity College Dublin
Total Publications: 30
Andrew John Fagan
Trinity College Dublin
Total Publications: 72
Francesco Amico
Trinity College Dublin
Total Publications: 8
Angela Carballedo
Trinity College Dublin
Total Publications: 23