Type

Journal Article

Authors

Daniel G Bradley
Eamonn P. Gormley
Brian Wickham
Donagh P. Berry
Emma K Finlay

Subjects

Microbiology

Topics
genetics genome wide association study genetic predisposition to disease tuberculosis bovine pathogenicity male veterinary mycobacterium bovis polymorphism single nucleotide phenotype animals genotype cattle

A genome wide association scan of bovine tuberculosis susceptibility in Holstein-Friesian dairy cattle. (2011)

Abstract Bovine tuberculosis is a significant veterinary and financial problem in many parts of the world. Although many factors influence infection and progression of the disease, there is a host genetic component and dissection of this may enlighten on the wider biology of host response to tuberculosis. However, a binary phenotype of presence/absence of infection presents a noisy signal for genomewide association study. We calculated a composite phenotype of genetic merit for TB susceptibility based on disease incidence in daughters of elite sires used for artificial insemination in the Irish dairy herd. This robust measure was compared with 44,426 SNP genotypes in the most informative 307 subjects in a genome wide association analysis. Three SNPs in a 65 kb genomic region on BTA 22 were associated (i.e. p<10(-5), peaking at position 59588069, pā€Š=ā€Š4.02Ɨ10(-6)) with tuberculosis susceptibility. A genomic region on BTA 22 was suggestively associated with tuberculosis susceptibility; it contains the taurine transporter gene SLC6A6, or TauT, which is known to function in the immune system but has not previously been investigated for its role in tuberculosis infection.
Collections Ireland -> Trinity College Dublin -> PubMed

Full list of authors on original publication

Daniel G Bradley, Eamonn P. Gormley, Brian Wickham, Donagh P. Berry, Emma K Finlay

Experts in our system

1
Daniel Bradley
Trinity College Dublin
Total Publications: 84
 
2
E Gormley
University College Dublin
Total Publications: 68
 
3
D P Berry
Teagasc
Total Publications: 243
 
4
Emma K Finlay
Teagasc
Total Publications: 11