Journal Article


J V Reynolds
G P Pidgeon
J Lysaght
A O'Grady
E Daly
M C Cathcart
S McGarrigle
S L Doyle
C L Donohoe



survival analysis waist circumference enzyme linked immunosorbent assay body mass index aged real time polymerase chain reaction male adult esophageal neoplasms pathology metabolism rna messenger humans middle aged adenocarcinoma insulin like growth factor i intra abdominal fat immunohistochemistry receptor igf type 1 female obesity abdominal genetics

Role of the insulin-like growth factor 1 axis and visceral adiposity in oesophageal adenocarcinoma. (2011)

Abstract Epidemiological studies have linked obesity with many cancers. The insulin-like growth factor (IGF) 1 axis may be an important mediator in obesity-associated cancer. This study examined the relationship between IGF-1 and its receptor (IGF-1R) in oesophageal adenocarcinoma, a cancer strongly linked to obesity. Patients with oesophageal adenocarcinoma considered suitable for attempted curative treatment were studied. Visceral adiposity was defined by waist circumference or visceral fat area. Free and total IGF-1 in serum were measured by enzyme-linked immunosorbent assay. Quantitative polymerase chain resection was used to determine mRNA expression of IGF-1 and IGF-1R in resected tumour samples. IGF-1R expression in tissue microarrays (TMAs) was quantified by immunohistochemistry. A total of 220 patients were studied. Total and free IGF-1 levels were significantly increased in the serum of viscerally obese patients. Gene expression analysis revealed a significant association between obesity status and both IGF-1R (P = 0·021) and IGF-1 (P = 0·031) in tumours. TMA analysis demonstrated that IGF-1R expression in resected tumours was significantly higher in viscerally obese patients than in those of normal weight (P = 0·023). Disease-specific survival was longer in patients with negative IGF-1R expression than in those with IGF-1R-positive tumours (median 60·0 versus 23·4 months; P = 0·027). This study highlighted the association of the IGF axis with visceral obesity, and a potential impact on the biology of oesophageal adenocarcinoma through its receptor. Targeting the IGF axis may have a rationale in future studies.
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Full list of authors on original publication

J V Reynolds, G P Pidgeon, J Lysaght, A O'Grady, E Daly, M C Cathcart, S McGarrigle, S L Doyle, C L Donohoe

Experts in our system

J V Reynolds
Trinity College Dublin
Total Publications: 206
Graham Pidgeon
Trinity College Dublin
Total Publications: 38
Joanne Lysaght
Trinity College Dublin
Total Publications: 39
Anthony O'Grady
Royal College of Surgeons in Ireland
Total Publications: 35
Mary Clare Cathcart
Trinity College Dublin
Total Publications: 16
Sarah A McGarrigle
Trinity College Dublin
Total Publications: 5
Sarah L Doyle
Trinity College Dublin
Total Publications: 51
Claire L Donohoe
Trinity College Dublin
Total Publications: 38