Type

Journal Article

Authors

Gary Donohoe
Aiden P Corvin
Michael Gill
Thomas Frodl
Hugh Garavan
Arun Bokde
Jane Mcgrath
Fiona N Newell
John O'Doherty
Sarah Jacobson
and 6 others

Subjects

Biochemistry

Topics
prefrontal cortex genetics memory short term brain male adult young adult physiology nitric oxide synthase type i humans organ size magnetic resonance imaging anatomy histology female

The NOS1 variant rs6490121 is associated with variation in prefrontal function and grey matter density in healthy individuals. (2011)

Abstract A common polymorphism within the nitric oxide sythanse-1 (NOS1) gene (rs6490121), initially identified as risk variant for schizophrenia, has been associated with variation in working memory and IQ. Here we investigated how this variation might be mediated at the level of brain structure and function. In healthy individuals (N=157), voxel based morphometry was used to compare grey matter (GM) volume between homozygous and heterozygous carriers of the 'G' allele (i.e. the allele associated with impaired cognition and schizophrenia risk) and homozygous carriers of the non-risk 'A' allele. Functional brain imaging data were also acquired from 48 participants during performance of a spatial working memory (SWM) task, and analysed to determine any effect of NOS1 risk status. An a priori region-of-interest analysis identified a significant reduction in ventromedial prefrontal GM volume in 'G' allele carriers. Risk carriers also exhibited altered patterns of activation in the prefrontal cortex, caudate, and superior parietal lobe, which were characteristic of abnormal increases in activation in frontoparietal working memory networks and a failure to disengage regions of the default mode network. These functional changes suggest a NOS1-mediated processing inefficiency, which may contribute to cognitive dysfunction in schizophrenia. While the mechanisms by which NOS1 may influence brain structure and/or function have not yet been well delineated, these data provide further evidence for a role of NOS1 in risk for schizophrenia via an impact upon cognitive function.
Collections Ireland -> Trinity College Dublin -> PubMed

Full list of authors on original publication

Gary Donohoe, Aiden P Corvin, Michael Gill, Thomas Frodl, Hugh Garavan, Arun Bokde, Jane Mcgrath, Fiona N Newell, John O'Doherty, Sarah Jacobson and 6 others

Experts in our system

1
Gary Donohoe
Trinity College Dublin
Total Publications: 130
 
2
Aiden Corvin
Trinity College Dublin
Total Publications: 190
 
3
Michael Gill
Trinity College Dublin
Total Publications: 260
 
4
Thomas Frodl
Trinity College Dublin
Total Publications: 58
 
5
Hugh Garavan
Trinity College Dublin
Total Publications: 160
 
6
Arun L W Bokde
Trinity College Dublin
Total Publications: 76
 
7
Jane Mcgrath
Trinity College Dublin
Total Publications: 11
 
8
Fiona N. Newell
Trinity College Dublin
Total Publications: 54
 
9
John P O'Doherty
Trinity College Dublin
Total Publications: 19