Type

Journal Article

Authors

Lorraine O'Driscoll
John Crown
Anne M Friel

Subjects

Biochemistry

Topics
tumor markers biological cytology mice neoplastic cells circulating endometrial neoplasms antigens surface dna neoplasm humans bone marrow mice scid female leukocytes mononuclear isolation purification neoplastic stem cells animals genetics metabolism gene expression regulation neoplastic

Analysis of gene expression as relevant to cancer cells and circulating tumour cells. (2011)

Abstract Current literature provides significant evidence to support the concept that there are limited subpopulations of cells within a solid tumour that have increased tumour-initiating potential relative to the total tumour population. Such tumour-initiating cells have been identified in leukaemia and in a variety of solid tumours using different combinations of cell surface markers, suggesting that a tumour-initiating cell heterogeneity exists for each specific tumour. These studies have been extended to endometrial cancer; and herein we present several experimental approaches, both in vitro and in vivo, that can be used to determine whether such populations exist, and if so, to characterize them. These methods are adaptable to the investigation of tumour-initiating cells from other tumour types.
Collections Ireland -> Trinity College Dublin -> PubMed

Full list of authors on original publication

Lorraine O'Driscoll, John Crown, Anne M Friel

Experts in our system

1
Lorraine O'Driscoll
Trinity College Dublin
Total Publications: 164
 
2
John Crown
Dublin City University
Total Publications: 104