Type

Journal Article

Authors

Lorraine O'Driscoll
John Crown
Linda Hughes
Susan McDonnell
Padraig Doolan
Martin Clynes
Grainne Gleeson
Sweta Rani
Susan Kennedy
Serena Germano

Subjects

Microbiology

Topics
neoplasm proteins adult breast neoplasms humans aged 80 and over treatment outcome cadherins cell movement neoplasm staging female genetics metabolism gene expression regulation neoplastic gene silencing tumor markers biological pathology epidemiology oligonucleotide array sequence analysis kaplan meier estimate middle aged antigens neoplasm cell line tumor aged maged1 protein human follow up studies neoplasm invasiveness cell adhesion prognosis

MAGE-D4B is a novel marker of poor prognosis and potential therapeutic target involved in breast cancer tumorigenesis. (2010)

Abstract Melanoma-associated antigen (MAGE) family members are generally described as tumor-specific antigens. An association between MAGE-D4B and breast cancer has yet to be reported and the functional role of the encoded protein has never been established. We performed microarray analysis of 104 invasive breast tumors and matched non-cancerous breast biopsies. qPCR was used for validation in an independent biobank. To investigate the biological relevance of MAGE-D4B in breast tumorigenesis, its phenotypic effects were assessed in vitro. Overall, MAGE-D4B was detected in 43% of tumors while undetected in normal breast tissue. MAGE-D4B was found to correlate with tumor progression and to be an independent prognostic marker for poor outcome in term of relapse-free and overall survival, with potential predictive relevance in relation to response to chemotherapy. RNA interference-mediated knockdown of MAGE-D4B significantly hampered the invasive properties of Hs578T cells by affecting anchorage-independent growth, adhesion, migration and invasion affecting anchorage-independent growth, adhesion, migration and invasion and by modulating expression of invasion-suppressor gene E-cadherin.
Collections Ireland -> Trinity College Dublin -> PubMed

Full list of authors on original publication

Lorraine O'Driscoll, John Crown, Linda Hughes, Susan McDonnell, Padraig Doolan, Martin Clynes, Grainne Gleeson, Sweta Rani, Susan Kennedy, Serena Germano

Experts in our system

1
Lorraine O'Driscoll
Trinity College Dublin
Total Publications: 152
 
2
John Crown
Dublin City University
 
3
Susan McDonnell
University College Dublin
Total Publications: 25
 
4
Padraig Doolan
Dublin City University
Total Publications: 37
 
5
Martin Clynes
Dublin City University
Total Publications: 209
 
6
Sweta Rani
Trinity College Dublin
Total Publications: 22
 
7
Susan Kennedy
Dublin City University
Total Publications: 37