Type

Journal Article

Authors

Gary Donohoe
Aiden Corvin
Michael Gill
Daniela Tropea
Doreen Hoerold
John J Foxe
Andreia Da Costa
Ciara Fahey
Derek W Morris
Therese O'Donoghue

Subjects

Psychiatry

Topics
child adolescent cognition psychomotor performance female genetics nitric oxide synthase type i electroencephalography visual perception nos1 protein human male young adult genetic variation physiology evoked potentials visual photic stimulation humans adult

A NOS1 variant implicated in cognitive performance influences evoked neural responses during a high density EEG study of early visual perception. (2010)

Abstract The nitric oxide synthasase-1 gene (NOS1) has been implicated in mental disorders including schizophrenia and variation in cognition. The NOS1 variant rs6490121 identified in a genome wide association study of schizophrenia has recently been associated with variation in general intelligence and working memory in both patients and healthy participants. Whether this variant is also associated with variation in early sensory processing remains unclear. We investigated differences in the P1 visual evoked potential in a high density EEG study of 54 healthy participants. Given both NOS1's association with cognition and recent evidence that cognitive performance and P1 response are correlated, we investigated whether NOS1's effect on P1 response was independent of its effects on cognition using CANTAB's spatial working memory (SWM) task. We found that carriers of the previously identified risk "G" allele showed significantly lower P1 responses than non-carriers. We also found that while P1 response and SWM performance were correlated, NOS1 continued to explain a significant proportion of variation in P1 response even when its effects on cognition were accounted for. The schizophrenia implicated NOS1 variants rs6490121 influences visual sensory processing as measured by the P1 response, either as part of the gene's pleiotropic effects on multiple aspects of brain function, or because of a primary influence on sensory processing that mediates the effects already seen in higher cognitive processes.
Collections Ireland -> Trinity College Dublin -> PubMed

Full list of authors on original publication

Gary Donohoe, Aiden Corvin, Michael Gill, Daniela Tropea, Doreen Hoerold, John J Foxe, Andreia Da Costa, Ciara Fahey, Derek W Morris, Therese O'Donoghue

Experts in our system

1
Gary Donohoe
Trinity College Dublin
Total Publications: 130
 
2
Aiden Corvin
Trinity College Dublin
Total Publications: 190
 
3
Michael Gill
Trinity College Dublin
Total Publications: 260
 
4
Daniela Tropea
Trinity College Dublin
Total Publications: 25
 
5
John J Foxe
Trinity College Dublin
Total Publications: 42
 
6
Ciara Fahey
Trinity College Dublin
Total Publications: 30
 
7
Derek Morris
Trinity College Dublin
Total Publications: 150