Type

Journal Article

Authors

Hugh Garavan
Ian H Robertson
Mark A. Bellgrove
Michael Gill
Aisling Mulligan
Edwina Barry
Ziarah Hawi
Caroline McDonnell
Ruth Acheson
Claire T Tobin
and 2 others

Subjects

Psychiatry

Topics
male brain magnetic resonance imaging anatomy histology reverse transcriptase polymerase chain reaction attention humans reaction time cognition dopamine plasma membrane transport proteins brain mapping slc6a3 protein human physiology attention deficit disorder with hyperactivity dna image processing computer assisted genotype adolescent female psychomotor performance psychology neuropsychological tests genetics

fMRI activation during response inhibition and error processing: the role of the DAT1 gene in typically developing adolescents and those diagnosed with ADHD. (2009)

Abstract The DAT1 gene codes for the dopamine transporter, which clears dopamine from the synaptic cleft, and a variant of this gene has previously been associated with compromised response inhibition in both healthy and clinical populations. This variant has also been associated with ADHD, a disorder that is characterised by disturbed dopamine function as well as problems with response inhibition. In the present study we used fMRI to investigate the role of dopaminergic genetic variation on executive functioning by comparing how activation associated with successful and unsuccessful inhibitions differs based on DAT1-genotype and ADHD-diagnosis in adolescents performing a go/nogo task. The results identify regional specificity concerning which functional differences can be attributed to the possession of the high risk DAT1 genotype, the clinical condition or an interaction between the two. During response inhibition, individuals with two copies of the 10-repeat allele showed increased activation in frontal, medial, and parietal regions, which may indicate that inhibition is more effortful for this group. Conversely, this group displayed a reduced error response in the parahippocampal gyrus, suggestive of reduced learning from errors. There were also a number of frontal, parietal, medial and occipital regions, where the relationship between genotype and fMRI-activation differed between the ADHD group and the typically developing adolescents. Finally, the ADHD group displayed decreased activation in parietal and (pre)frontal regions during response inhibition, and in frontal and medial brain regions on error trials.
Collections Ireland -> Trinity College Dublin -> PubMed

Full list of authors on original publication

Hugh Garavan, Ian H Robertson, Mark A. Bellgrove, Michael Gill, Aisling Mulligan, Edwina Barry, Ziarah Hawi, Caroline McDonnell, Ruth Acheson, Claire T Tobin and 2 others

Experts in our system

1
Hugh Garavan
Trinity College Dublin
Total Publications: 160
 
2
Ian H Robertson
Trinity College Dublin
Total Publications: 142
 
3
Mark A. Bellgrove
Trinity College Dublin
Total Publications: 35
 
4
Michael Gill
Trinity College Dublin
Total Publications: 260
 
5
Aisling Mulligan
Trinity College Dublin
Total Publications: 10