Type

Journal Article

Authors

Lorraine O'Driscoll
John Crown
Michael J Duffy
Anne M Friel
Claire Corcoran

Subjects

Microbiology

Topics
humans metabolism antineoplastic agents neoplasm invasiveness molecular targeted therapy female therapeutic use micrornas prognosis neoplasm metastasis drug resistance neoplasm genetics tumor markers biological diagnosis male extracellular space drug therapy breast neoplasms breast neoplasms male oncogenes intracellular space

Intracellular and extracellular microRNAs in breast cancer. (2010)

Abstract Successful treatment of breast cancer is enhanced by early detection and, if possible, subsequent patient-tailored therapy. Toward this goal, it is essential to identify and understand the most relevant panels of biomarkers, some of which may also have relevance as therapeutic targets. We critically reviewed published literature on microRNAs (miRNAs) as relevant to breast cancer. Since the initial recognition of the association of miRNAs with breast cancer in 2005, studies involving cell lines, in vivo models, and clinical specimens have implicated several functions for miRNAs, including suppressing oncogenesis and tumors, promoting or inhibiting metastasis, and increasing sensitivity or resistance to chemotherapy and targeted agents in breast cancer. For example, miR-21 is overexpressed in both male and female breast tumors compared with normal breast tissue and has been associated with advanced stage, lymph node positivity, and reduced survival time. miR-21 knock-down in cell-line models has been associated with increased sensitivity to topotecan and taxol in vitro and the limitation of lung metastasis in vivo. Furthermore, the discovery of extracellular miRNAs (including miR-21), existing either freely or in exosomes in the systemic circulation, has led to the possibility that such molecules may serve as biomarkers for ongoing patient monitoring. Although additional investigations are necessary to fully exploit the use of miRNAs in breast cancer, there is increasing evidence that miRNAs have potential not only to facilitate the determination of diagnosis and prognosis and the prediction of response to treatment, but also to act as therapeutic targets and replacement therapies.
Collections Ireland -> Trinity College Dublin -> PubMed

Full list of authors on original publication

Lorraine O'Driscoll, John Crown, Michael J Duffy, Anne M Friel, Claire Corcoran

Experts in our system

1
Lorraine O'Driscoll
Trinity College Dublin
Total Publications: 164
 
2
John Crown
Dublin City University
Total Publications: 104
 
3
Michael J Duffy
University College Dublin
 
4
Claire Corcoran
Trinity College Dublin