Type

Journal Article

Authors

Aiden Corvin
Derek W Morris
Gary Donohoe

Subjects

Biochemistry

Topics
genetics genome wide association study genes society znf804a protein human diagnosis genetic predisposition to disease brain mapping physiopathology brain psychosis susceptibility neuropsychological tests znf804a phenotypes humans chromosome mapping kruppel like transcription factors polymorphism single nucleotide phenotype schizophrenia neuroscience genotype dna copy number variations schizophrenic psychology

The psychosis susceptibility gene ZNF804A: associations, functions, and phenotypes. (2010)

Abstract As the first gene to have achieved genome-wide significance for psychosis, ZNF804A has predictably been a subject of intense research activity. We review the evidence to date for the association between schizophrenia and the original risk variant rs1344706 identified as well as additional common and rare variants at this locus. We describe the still scant literature on the biological function of ZNF804A and discuss the efforts being made to characterize and refine the associated phenotype using imaging and neuropsychological approaches. We conclude that ZNF804A is robustly, if modestly, associated with schizophrenia risk, with much work still remaining to elucidate its role in schizophrenia biology.
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Full list of authors on original publication

Aiden Corvin, Derek W Morris, Gary Donohoe

Experts in our system

1
Aiden Corvin
Trinity College Dublin
Total Publications: 190
 
2
Derek Morris
Trinity College Dublin
Total Publications: 150
 
3
Gary Donohoe
Trinity College Dublin
Total Publications: 130