Type

Journal Article

Authors

J V Reynolds
G P Pidgeon
M Keogan
D Ennis
P Beddy
J M Howard

Subjects

Biochemistry

Topics
esophageal neoplasms neoplasm staging humans etiology adenocarcinoma intra abdominal fat female esophagogastric junction obesity abdominal adipor1 protein human complications metabolism adipokines receptors adiponectin adipor2 protein human pathology up regulation male cell line tumor enzyme linked immunosorbent assay receptors leptin middle aged

Associations between leptin and adiponectin receptor upregulation, visceral obesity and tumour stage in oesophageal and junctional adenocarcinoma. (2010)

Abstract Obesity is associated with oesophageal adenocarcinoma, but mechanisms linking fat and carcinogenesis remain poorly understood. Altered circulating adipocytokines may be important. This study aimed to identify pathways through which visceral fat impacts on tumour biology. Seventy-five patients with oesophageal adenocarcinoma underwent anthropometric and radiological assessment of obesity. Expression of leptin receptor (ObR) and adiponectin receptors 1 and 2 (AdipR1, AdipR2) was quantified by real-time reverse transcriptase-polymerase chain reaction. The human oesophageal adenocarcinoma cell line OE33 was used as the calibrator sample. Ninety-one per cent of tumours expressed ObR, 95 per cent expressed AdipR1 and 100 per cent expressed AdipR2. Relative expression of ObR was upregulated in 67 per cent, and AdipR1 and AdipR2 were downregulated in 55 and 68 per cent respectively, relative to the calibrator sample. Upregulated ObR and AdipR2 expression was significantly associated with anthropometric and radiological measures of obesity. Upregulated ObR was associated with advanced tumour and node category (P = 0.036 and P = 0.025 respectively), and upregulated AdipR2 with nodal involvement (P = 0.037). Obesity is associated with upregulated ObR and AdipR2 expression in oesophageal adenocarcinoma. The association of ObR and AdipR2 with tumour stage suggest that pathways involving adipocytokines affect tumour biology.
Collections Ireland -> Trinity College Dublin -> PubMed

Full list of authors on original publication

J V Reynolds, G P Pidgeon, M Keogan, D Ennis, P Beddy, J M Howard

Experts in our system

1
J V Reynolds
Trinity College Dublin
Total Publications: 206
 
2
Graham Pidgeon
Trinity College Dublin
Total Publications: 38
 
3
P Beddy
Trinity College Dublin
Total Publications: 6