Journal Article


Lorraine O'Driscoll
John Crown
Claire Corcoran
Anne M Friel



genetic markers tumor markers biological pathology nucleic acids blood neoplastic cells circulating exosomes breast neoplasms humans mortality rna messenger micrornas female predictive value of tests animals genetics early detection of cancer prognosis metabolism gene expression regulation neoplastic diagnosis

Relevance of circulating tumor cells, extracellular nucleic acids, and exosomes in breast cancer. (2009)

Abstract Early detection of cancer is vital to improved overall survival rates. At present, evidence is accumulating for the clinical value of detecting occult tumor cells in peripheral blood, plasma, and serum specimens from cancer patients. Both molecular and cellular approaches, which differ in sensitivity and specificity, have been used for such means. Circulating tumor cells and extracellular nucleic acids have been detected within blood, plasma, and sera of cancer patients. As the presence of malignant tumors are clinically determined and/or confirmed upon biopsy procurement-which in itself may have detrimental effects in terms of stimulating cancer progression/metastases-minimally invasive methods would be highly advantageous to the diagnosis and prognosis of breast cancer and the subsequent tailoring of targeted treatments for individuals, if reliable panels of biomarkers suitable for such an approach exist. Herein, we review the current advances made in the detection of such circulating tumor cells and nucleic acids, with particular emphasis on extracellular nucleic acids, specifically extracellular mRNAs and discuss their clinical relevance.
Collections Ireland -> Trinity College Dublin -> PubMed

Full list of authors on original publication

Lorraine O'Driscoll, John Crown, Claire Corcoran, Anne M Friel

Experts in our system

Lorraine O'Driscoll
Trinity College Dublin
Total Publications: 164
John Crown
Dublin City University
Total Publications: 104
Claire Corcoran
Trinity College Dublin