Type

Journal Article

Authors

Elisabeth Vandenberghe
Eibhlin Conneally
Paul V Browne
Shaun R McCann
Mairead Ní Chonghaile
Lorraine Brennan
Nick Chadwick
Ruth Gilmore
Hilary O'Leary
Anne Fortune

Subjects

Medicine & Nursing

Topics
retrospective studies male therapeutic use adult combined modality therapy young adult therapy kaplan meier estimate humans middle aged adolescent female antineoplastic combined chemotherapy protocols treatment outcome precursor cell lymphoblastic leukemia lymphoma hematopoietic stem cell transplantation

T-lymphoblastic leukemia/lymphoma: a single center retrospective study of outcome. (2010)

Abstract T-lymphoblastic leukemia/lymphoma (LBL and ALL) is a rare lymphoid malignancy typically presenting in adolescent and young adult males. Patients are traditionally treated with ALL-type protocols, with no consensus on the role of maintenance therapy, or allogeneic or autologous transplant. Outcome results are thus difficult to interpret. The successful use of intensified ALL protocols in patients <25 years with lymphoblastic malignancies without transplant prompted the Haematology Unit at St James's Hospital (SJH) to change practice in 2005 from transplanting in first complete remission (CR1) to treating patients <25 years with chemotherapy alone. We reviewed the outcome of patients treated before 2005 in order to compare the pre- and post-2005 management approaches in the future. This retrospective study included 31 patients with T-LBL treated from 1980 to 2004. The patients were divided into group A (16-25 years) and group B (>25 years). Twenty-one patients had an allograft in CR1 (group A, n = 12 and group B, n = 9). For the allografted patients the 5-year EFS and OS was 57%, with a treatment related mortality of 10%. In conclusion, this series confirms that allograft in CR1 has an acceptable cure rate, and we will use these results to benchmark outcomes using pediatric-type protocols in the future.
Collections Ireland -> Trinity College Dublin -> PubMed

Full list of authors on original publication

Elisabeth Vandenberghe, Eibhlin Conneally, Paul V Browne, Shaun R McCann, Mairead Ní Chonghaile, Lorraine Brennan, Nick Chadwick, Ruth Gilmore, Hilary O'Leary, Anne Fortune

Experts in our system

1
E Vandenberghe
Trinity College Dublin
Total Publications: 8
 
2
E Conneally
Trinity College Dublin
Total Publications: 3
 
3
Paul V Browne
Trinity College Dublin
Total Publications: 12
 
4
Lorraine Brennan
University College Dublin
Total Publications: 166
 
5
Hilary O'Leary
University of Limerick
Total Publications: 4