Type

Journal Article

Authors

Richard J L Anney
Louise Gallagher
Lindsey Kent
Astrid Vicente
Catarina Correia
David Skuse
Michael Gill
Lynne E Cochrane
Matthew J Hill
Keeley J Brookes
and 1 others

Subjects

Psychiatry

Topics
genetic predisposition to disease polymorphism single nucleotide genetics humans genotype autistic disorder european continental ancestry group receptors oxytocin

Oxytocin receptor (OXTR) does not play a major role in the aetiology of autism: genetic and molecular studies. (2009)

Abstract Oxytocin (OXT) has been hypothesized to play a role in aetiology of autism based on a demonstrated involvement in the regulation of social behaviours. It is postulated that OXT reduces activation of the amygdala, inhibiting social anxiety, indicating a neural mechanism for the effects of OXT in social cognition. Genetic variation at the oxytocin receptor gene (OXTR) has been reported to be associated with autism. We examined 18 SNPs at the OXTR gene for association in three independent autism samples from Ireland, Portugal and the United Kingdom. We investigated cis-acting genetic effects on OXTR expression in lymphocytes and amygdala region of the brain using an allelic expression imbalance (AEI) assay and by investigating the correlation between RNA levels and genotype in the amygdala region. No marker survived multiple correction for association with autism in any sample or in a combined sample (n=436). Results from the AEI assay performed in the lymphoblast cell lines highlighted two SNPs associated with relative allelic abundance in OXTR (rs237897 and rs237895). Two SNPs were found to be effecting cis-acting variation through AEI in the amygdala. One was weakly correlated with total gene expression (rs13316193) and the other was highlighted in the lymphoblast cell lines (rs237895). Data presented here does not support the role of common genetic variation in OXTR in the aetiology of autism spectrum disorders in Caucasian samples.
Collections Ireland -> Trinity College Dublin -> PubMed

Full list of authors on original publication

Richard J L Anney, Louise Gallagher, Lindsey Kent, Astrid Vicente, Catarina Correia, David Skuse, Michael Gill, Lynne E Cochrane, Matthew J Hill, Keeley J Brookes and 1 others

Experts in our system

1
Richard Anney
Trinity College Dublin
Total Publications: 38
 
2
Louise Gallagher
Trinity College Dublin
Total Publications: 55
 
3
Michael Gill
Trinity College Dublin
Total Publications: 260
 
4
Matthew Hill
Trinity College Dublin
Total Publications: 10