Journal Article


Harald Hampel
Hans-Juergen Möller
Maximilian F Reiser
Frank Faltraco
Stefen J Teipel
Thomas Meindl
Michael Ewers
Christine Born
Patricia Lopez-Bayo
Arun L W Bokde



visual cortex photic stimulation alzheimer disease physiopathology visual perception case control studies male adult neuropsychological tests physiology aged task performance and analysis humans brain mapping magnetic resonance imaging female

Alzheimer disease: functional abnormalities in the dorsal visual pathway. (2009)

Abstract To evaluate whether patients with Alzheimer disease (AD) have altered activation compared with age-matched healthy control (HC) subjects during a task that typically recruits the dorsal visual pathway. The study was performed in accordance with the Declaration of Helsinki, with institutional ethics committee approval, and all subjects provided written informed consent. Two tasks were performed to investigate neural function: face matching and location matching. Twelve patients with mild AD and 14 age-matched HC subjects were included. Brain activation was measured by using functional magnetic resonance imaging. Group statistical analyses were based on a mixed-effects model corrected for multiple comparisons. Task performance was not statistically different between the two groups, and within groups there were no differences in task performance. In the HC group, the visual perception tasks selectively activated the visual pathways. Conversely in the AD group, there was no selective activation during performance of these same tasks. Along the dorsal visual pathway, the AD group recruited additional regions, primarily in the parietal and frontal lobes, for the location-matching task. There were no differences in activation between groups during the face-matching task. The increased activation in the AD group may represent a compensatory mechanism for decreased processing effectiveness in early visual areas of patients with AD. The findings support the idea that the dorsal visual pathway is more susceptible to putative AD-related neuropathologic changes than is the ventral visual pathway.
Collections Ireland -> Trinity College Dublin -> PubMed

Full list of authors on original publication

Harald Hampel, Hans-Juergen Möller, Maximilian F Reiser, Frank Faltraco, Stefen J Teipel, Thomas Meindl, Michael Ewers, Christine Born, Patricia Lopez-Bayo, Arun L W Bokde

Experts in our system

Harald Hampel
Trinity College Dublin
Total Publications: 35
Arun L W Bokde
Trinity College Dublin
Total Publications: 144