Type

Journal Article

Authors

Gianfranco Spalletta
Aiden P Corvin
Michael Gill
Colm McDonald
Paola Bossù
Carlo Caltagirone
Andrea Cherubini
Dara M. Cannon
Ilaria Spoletini
Derek Morris
and 2 others

Subjects

Psychiatry

Topics
magnetic resonance imaging adult humans carrier proteins analysis of variance psychiatric status rating scales physiopathology occipital lobe female genetic predisposition to disease image processing computer assisted memory short term genetics male neuropsychological tests pathology physiology memory disorders middle aged schizophrenia brain mapping electroencephalography etiology prefrontal cortex haplotypes dtnbp1 protein human

Reduced occipital and prefrontal brain volumes in dysbindin-associated schizophrenia. (2009)

Abstract A three-marker C-A-T dysbindin haplotype identified by Williams et al (PMID: 15066891) is associated with increased risk for schizophrenia, decreased mRNA expression, poorer cognitive performance, and early sensory processing deficits. We investigated whether this same dysbindin risk haplotype was also associated with structural variation in the gray matter volume (GMV). Using voxel-based morphometry, whole-volume analysis revealed significantly reduced GMVs in both the right dorsolateral prefrontal and left occipital cortex, corresponding to the behavioral findings of impaired spatial working memory and EEG findings of impaired visual processing already reported. These data provide important evidence of the influence of dysbindin risk variants on brain structure, and suggest a possible mechanism by which disease risk is being increased.
Collections Ireland -> Trinity College Dublin -> PubMed

Full list of authors on original publication

Gianfranco Spalletta, Aiden P Corvin, Michael Gill, Colm McDonald, Paola Bossù, Carlo Caltagirone, Andrea Cherubini, Dara M. Cannon, Ilaria Spoletini, Derek Morris and 2 others

Experts in our system

1
Gianfranco Spalletta
Trinity College Dublin
Total Publications: 5
 
2
Aiden Corvin
Trinity College Dublin
Total Publications: 190
 
3
Michael Gill
Trinity College Dublin
Total Publications: 260
 
4
Colm McDonald
National University of Ireland Galway
Total Publications: 43
 
5
Paola Bossù
Trinity College Dublin
Total Publications: 4
 
6
Carlo Caltagirone
Trinity College Dublin
Total Publications: 4
 
7
Dara M. Cannon
National University of Ireland Galway
Total Publications: 29
 
8
Derek Morris
Trinity College Dublin
Total Publications: 150